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Bahrami, Afsane; Shams, Seyyede Fatemeh; Eidgahi, Elham Shaarbaf; Lotfi, Zahra; Sheikhi, Maryam; Shakeri, Sepideh

doi:10.6002/ect.2016.0068

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…Our readmission rate is much higher than the infection-related readmissions found in the United States Renal Data System (12%) [ 8 ] and Canada (21% within 30 days and 28.1% within 90 days) [ 15 ]. However, it is similar to the findings of studies from Iran (51% and 49.6%) [ 5 , 16 ]. The tendency of increased infectious events after transplant has been attributed to the use of immunosuppressive drugs, exposure to nosocomial pathogens, and the need for invasive intravascular and urinary devices.…”

Section: Discussionsupporting

confidence: 91%

“…The most common infection found in our study was UTI, which correlates with studies from Canada [ 15 ], Iran [ 16 ], and Colombia [ 17 ]. In addition, a study from our centre found that 33% of renal transplant recipients had at least one episode of urinary tract infection, and the structural abnormalities, renal stone disease, delay in removing Foley's catheter, and increased post-transplant hospital stay are risk factors leading to UTI in renal transplant recipients [ 18 ].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Re-Hospitalization in First Six Months After Live Related Renal Transplantation: Risk Factors, Burden, Causes and Outcomes

Dashti¹,

Dhrolia²,

Nasir³

et al. 2022

Cureus

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The aim of our study was to evaluate the incidence, causes, risk factors, outcomes, and cost of hospital readmission after live related renal transplantation (LRRT). MethodsWe conducted a cross-sectional study and followed patients' re-admissions for six months whose LRRT was done in our center between September 2019 and June 2020. ResultsWe recruited 53 patients, 40 (75.5%) were male. The mean age was 36.9 ± 11.9 years. Donor gender was similar, and their mean age was 31.6 ± 9.2 years. The mean length of hospital stay after LRRT was 14 ± 2.2 days. A total of 81.1% were readmitted after LRRT within the first six months, with a total of 113 readmissions. The median time of readmission after LRRT was 66 days. The median readmission hospital stay was four days. The causes of readmission were surgical in 11 (9.7%), medical in 89 (78.8%), and combined medical and surgical in 13 (11.5%). Infection was the most common medical cause, followed by rejection. Statistically significant difference between readmission and non-readmission groups was found in estimated glomerular filtration rate (eGFR) at six month 61.3 ± 25.9 vs. 84.3 ± 36.1 mL/min/1.73 m 2 respectively (p = 0.02). The median cost of readmission was PKR 40629, equivalent to USD 261. ConclusionOver three-fourths of the patients were readmitted after LRRT within the first six months. The most common causes were infection and rejection. Readmissions after LRRT are associated with lower graft function at six months and a significant cost burden on the health system.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Re-Hospitalization in First Six Months After Live Related Renal Transplantation: Risk Factors, Burden, Causes and Outcomes

Dashti¹,

Dhrolia²,

Nasir³

et al. 2022

Cureus

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“…Our study investigates the impact of sex and age in a complex patient population at high risk for infections and resulting infectious complications. 36 , 37 , 38 , 39 In the general population, males have a significantly higher COVID‐19‐related mortality than females do. 3 , 5 Estradiol is generally immune enhancing and testosterone immune suppressing 40 thus in the immunocompetent state, females have a more robust anti‐viral immune response than males.…”

Section: Discussionmentioning

confidence: 99%

Sex and organ-specific risk of major adverse renal or cardiac events in solid organ transplant recipients with COVID-19

Vinson

Dai

Agarwal

et al. 2022

American Journal of Transplantation

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While older males are at the highest risk for poor coronavirus disease 2019 (COVID‐19) outcomes, it is not known if this applies to the immunosuppressed recipient of a solid organ transplant (SOT), nor how the type of allograft transplanted may impact outcomes. In a cohort study of adult (>18 years) patients testing positive for COVID‐19 (January 1, 2020‐June 21, 2021) from 56 sites across the United States identified using the National COVID Cohort Collaborative (N3C) Enclave, we used multivariable Cox proportional hazards models to assess time to MARCE after COVID‐19 diagnosis in those with and without SOT. We examined the exposure of age‐stratified recipient sex overall and separately in kidney, liver, lung, and heart transplant recipients. 3996 (36.4%) SOT and 91 646 (4.8%) non‐SOT patients developed MARCE. Risk of post‐COVID outcomes differed by transplant allograft type with heart and kidney recipients at highest risk. Males with SOT were at increased risk of MARCE, but to a lesser degree than the non‐SOT cohort (HR 0.89, 95% CI 0.81–0.98 for SOT and HR 0.61, 95% CI 0.60–0.62 for non‐SOT [females vs. males]). This represents the largest COVID‐19 SOT cohort to date and the first‐time sex‐age–stratified and allograft‐specific COVID‐19 outcomes have been explored in those with SOT.

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“…P. aeruginosa was also the most commonly detected pathogen in RI patients. E. coli was reportedly the most commonly isolated pathogen in KTRs in multiple previous studies, [22–24] but the etiology of RI was not evaluated in these studies. In a study investigating potential therapeutic targets, P. aeruginosa was the sixth most common repeat-occurrence pathogen.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and etiology of repeat infection in kidney transplant recipients

Chen

et al. 2019

Medicine

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Kidney transplantation (KT) is the best therapy available for patients with end-stage renal disease, but postoperative infections are a significant cause of mortality.In this retrospective study the frequency, risk factors, causative pathogens, and clinical manifestations of infection in KT recipients from Beijing Chao-Yang Hospital, Capital Medical University were investigated. Ninety-seven KT recipients who were hospitalized with infection between January 2010 and December 2016 were included. Clinical characteristics, surgery details, laboratory results, and etiology were compared in patients who developed single infection and patients who developed repeated infection (2 or more) after KT.A total of 161 infections were adequately documented in a total of 97 patients, of which 57 patients (58.8%) had 1 infection, 24 (24.7%) had 2, 11 (11.3%) had 3; 3 (3.1%) had 4, and 2 (2.1%) had 5 or more. The most common infection site was the urinary tract (90 infections; 56%), both overall and in the repeated infection group. The most frequently isolated pathogen was Pseudomonas aeruginosa. In the repeated infection patients, in most cases of P. aeruginosa infection (54%) it was cultured from urine. For first infections, a time between KT and infection of ≤ 21 days (area under receiver operating characteristic curve [AUC] 0.636) and a tacrolimus level ≥ 8 ng/mL (AUC 0.663) independently predicted repeat infection. The combination of these two predictive factors yielded an AUC of 0.716, which did not differ statistically significantly from either predictor alone.With regard to first infections after KT, a time between KT and infection of ≤ 21 days, and a tacrolimus level ≥ 8 ng/mL each independently predicted repeated infection in KT recipients.

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Abstract: Infections are highly prevalent during the first year after transplant. Prevention and effective antibiotic therapy can reduce the related adverse effects.

Cited by 6 publications

References 24 publications

Re-Hospitalization in First Six Months After Live Related Renal Transplantation: Risk Factors, Burden, Causes and Outcomes

Re-Hospitalization in First Six Months After Live Related Renal Transplantation: Risk Factors, Burden, Causes and Outcomes

Sex and organ-specific risk of major adverse renal or cardiac events in solid organ transplant recipients with COVID-19

Risk factors and etiology of repeat infection in kidney transplant recipients

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