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Abstract

In recent times many chemical drugs are capable of causing the side effects to the humans; in order to avoid these side effects herbal based drugs is essential for the better substitute.Plants have a long history of use in the treatment of cancer. Plant-derived compounds have played an important role in the development of several clinically useful anticancer agents. The scientific analysis is carried out all over in India since Vedic times and are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) proposed for their valuable anticancer and other valuable properties. Numerous forms of cancer accounts for 10% of total death worldwide which requires better therapeutic approaches. Ginger is one of the most commonly used herbal medicines for the treatment of numerous ailments and improvement of body functions.Compounds of ginger (Zingiber officinale), shown to exhibit antioxidant, anti-inflammatory and anti-carcinogenic properties. In current study, we intended to analyze inhibitory properties of ginger towards target proteins for several cancers by computer aided virtual screening. Docking study revealed that compounds gingerol, shogaol, zingiberol, zingiberene, zingerone, zingerdiol were found to have strong binding affinity towards selected cancer targets. Hence, these compounds can be further investigated in vitro and in vivo to develop novel chemical scaffold on which further derivatization can be done for further optimization of its anticancer activity.