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Chemical Constituents and Bioactivities of Starfish

“…The compounds exhibited modest in vitro cytotoxicities towards a panel of human tumor cell lines. The polyhydroxy sterol ketone 174 was reported from the Far Eastern starfish Henricia sanguinolenta and H. leviuscula [58]. Compound 174 mildly inhibited division of fertilised sea urchin eggs.…”

“…Asteriidoside L (413), a moderately cytotoxic steroidal saponin, was isolated from an unidentified Antarctic starfish of the family Asteriidae [112]. The monoglycosylated steroid sanguinoside C (414) [58] [61]. Henricia aspera was the source of asperosides A and B (417 and 418, resp.…”

Steroid Compounds from Far Eastern Starfishes Henricia aspera and H. tumida

“…2 We continue the study of physiologically active polyhydroxylated steroids and their derivatives from various starfish species of the family Echinasteridae [2][3][4] and, in this work, from extracts of Far Eastern starfishes H. aspera and H. tumida , isolated four new glycosides that have polyhydroxylated steroid moieties with the attached at C3 2,3-di-O -methyl-or, again, 2,4-di-O -methyl-D -xylosyl residues. Two new steroid polyols and three already known steroid glycosides were also identified in the two starfish species.…”

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lowed by HPLC on ODS-A and Silasorb C 18 columns as described in [4]. The structure elucidation of ( I )-( VI ) was mainly carried out by spectral methods (NMR, MALDI TOF and EI MS (see Tables 1-4 and the Experimental section).

The quasimolecular ion peak [ M + Na] + at m / z 663 in the MALDI TOF MS (registration of cations) and the 13 C and 1 H NMR spectra of ( I ) correspond to the molecular formula ë 35 H 60 O 10 of the compound.

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“…lowed by HPLC on ODS-A and Silasorb C 18 columns as described in [4]. The structure elucidation of ( I )-( VI ) was mainly carried out by spectral methods (NMR, MALDI TOF and EI MS (see Tables 1-4 and the Experimental section).…”