Untitled

Ivanitskii, Genrikh R.; Kresteva, I.B.; Khizhnyak, E. P.; Deev, A. A.; Rudneva, O. A.

doi:10.1023/a:1026640410526

Cited by 3 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The intravenous LD 50 of Fluosol was estimated at 26−29 and 35 g of PFC/kg b.w. in rats for 20% and 35% w/v concentrated emulsions, respectively, indicating that the volume injected (130−145 and 101 mL/kg, respectively) may have had a part in this toxicity. , Similar figures were reported for Perftoran . For PFOB, the LD 50 reached 41 g/kg b.w.…”

Section: Acute Toxicitysupporting

confidence: 66%

“…These gaps are particularly large when the patient suffers from anemia or is hemodiluted. Cell-free Hb molecules, Hb-loaded liposomes, and PFC droplets, by filling these gaps in large numbers, increase O 2 content and potentially facilitate O 2 diffusion by providing numerous “stepping stones” or dynamic chains of particles over which O 2 can travel. − Much more numerous than RBCs, such particles also offer a several orders of magnitude larger area for gas exchange. In the larger vessels, a near-wall excess of the smaller particles is likely to develop as RBCs would tend to migrate nearer the lower shear central axis of the vessel.…”

Section: Oxygen Diffusion and Oxygen Diffusion Facilitationmentioning

confidence: 99%

“…The small 0.1−0.2 μm-size droplets will circulate more easily in the capillary beds than the 30−70 times larger RBCs. The movement of emulsion microdroplets in the blood stream was proposed to create dynamic chains of particles; hence, channels which would help transfer O 2 from the RBCs to tissues . The probability of formation of such channels increases sharply when the size of the particles decreases and their number increases.…”

Section: Oxygen Diffusion and Oxygen Diffusion Facilitationmentioning

confidence: 99%

“…The movement of emulsion microdroplets in the blood stream was proposed to create dynamic chains of particles; hence, channels which would help transfer O 2 from the RBCs to tissues. 372 The probability of formation of such channels increases sharply when the size of the particles decreases and their number increases. Numerous [385][386][387][388] (section V.G).…”

Section: Oxygen Diffusion and Oxygen Diffusion Facilitationmentioning

confidence: 99%

“…222,386,[1417][1418][1419] Another emulsion, similar to Fluosol in many respects (∼11% PFC by volume; also based primarily on FDC, and incorporating a higher MW cyclic tertiary F-alkylamine, namely, FMCP 5.6, also using a poloxamer as the emulsifier, was developed in Russia under the tradename Perftoran (Russian Academy of Sciences/Perftoran Company, Pushshino, Russia; this emulsion was initially known as Ftorosan). 162,372,1420,1421 An organ half-life of 90 days has been reported for FMCP. 1422 Perftoran, which is filtersterilized, is stable for about 1 month at 4-8 °C but requires freezing for longer storage.…”

Section: The First Commercial Emulsionssfluosol-damentioning

confidence: 99%

See 4 more Smart Citations

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

View full text Add to dashboard Cite

Pharmaceutical Corporation in San Diego; however, the opinion expressed here are solely his and not necessarily those of the Corporation. Jean G. Riess received his chemical engineer and doctorat-e `s-sciences degrees (the latter with Professor Guy Ourisson in 1963) from the University of Strasbourg. He then spent two years with John Van Wazer at Monsanto in Saint-Louis, MO, learning some phosphorus and transitionmetal chemistry. In 1968 he became Professor at the University of Nice, France, where he founded, directed, and eventually became honorary director of the Unite ´de Chimie Mole ´culaire (associated with the Centre National de la Recherche Scientifique). His research successively involved phosphorus chemistry, transition-metal chemistry, organometallics, and eventually perfluorochemicals. His present interests are in fluorocarbons, fluorinated amphiphiles, and their colloid chemistry, including fluorocarbon emulsions for in vivo O 2 delivery, fluorinated self-assemblies, and drug delivery systems. Professor Riess has published about 360 papers and holds ca. 25 patents. He has served on numerous councils and committees and has chaired or co-chaired international conferences on phosphorus chemistry and blood substitutes. He has won awards from the French Academy of Sciences, French Chemical Society, Alexander von Humboldt Stifftung, City of Nice and Controlled Release Society, as well as Alliance's first Distinguished Contribution Award. He holds an honorary Research Associate position at the University of California at San Diego and sits on the Board of Directors of Alliance Pharmaceutical Corp.

show abstract

Section: Acute Toxicitysupporting

confidence: 66%

Section: Oxygen Diffusion and Oxygen Diffusion Facilitationmentioning

confidence: 99%

Section: Oxygen Diffusion and Oxygen Diffusion Facilitationmentioning

confidence: 99%

Section: Oxygen Diffusion and Oxygen Diffusion Facilitationmentioning

confidence: 99%

Section: The First Commercial Emulsionssfluosol-damentioning

confidence: 99%

See 3 more Smart Citations

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

View full text Add to dashboard Cite

show abstract

A Generalized System for Photoresponsive Membrane Rupture in Polymersomes

Kamat

Robbins

Rawson

et al. 2010

Adv Funct Materials

View full text Add to dashboard Cite

Polymersomes are vesicles whose membranes are comprised of self-assembled block co-polymers. We recently showed that co-encapsulating conjugated multi-porphyrin dyes in a polymersome membrane with ferritin protein in the aqueous lumen confers photo-lability to the polymersome. In the present study, we illustrate that the photo-lability can be extended to vesicles containing dextran, an inert and inexpensive polysaccharide, as the luminal solute. Here we explore how structural features of the polymersome/porphyrin/dextran composite affect its photo-response. Increasing dextran molecular weight, decreasing block copolymer molecular weight, and altering fluorophore-membrane interactions results in increasing the photo-responsiveness of the polymersomes. Amphiphilic interactions of the luminal encapsulant with the membrane coupled with localized heat production in the hydrophobic bilayer likely cause differential thermal expansion in the membrane and the subsequent membrane rupture. This study suggests a general approach to impart photo-responsiveness to any biomimetic vesicle system without chemical modification, as well as a simple, bio-inert method for constructing photo-sensitive carriers for controlled release of encapsulants.

show abstract

A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone

et al. 2018

View full text Add to dashboard Cite

Ubiquinone (UQ) is a polyprenylated lipid that is conserved from bacteria to humans and is crucial to cellular respiration. How the cell orchestrates the efficient synthesis of UQ, which involves the modification of extremely hydrophobic substrates by multiple sequential enzymes, remains an unresolved issue. Here, we demonstrate that seven Ubi proteins form the Ubi complex, a stable metabolon that catalyzes the last six reactions of the UQ biosynthetic pathway in Escherichia coli. The SCP2 domain of UbiJ forms an extended hydrophobic cavity that binds UQ intermediates inside the 1 MDa Ubi complex. We purify the Ubi complex from cytoplasmic extracts and demonstrate that UQ biosynthesis occurs in this fraction, challenging the current thinking of a membrane-associated biosynthetic process. Collectively, our results document a rare case of stable metabolon and highlight how the supramolecular organization of soluble enzymes allows the modification of hydrophobic substrates in a hydrophilic environment. Besides the Ubi enzymes that catalyze the chemical reactions of the pathway (Figure 1A), three Ubi proteins of unknown function are also required for efficient UQ biosynthesis, UbiB (Poon et al., 2000), UbiJ (Aussel et al., 2014a) and UbiK (Loiseau et al., 2017). Lately, we demonstrated that purified UbiJ and UbiK form a 1:2 heterocomplex that binds palmitoleic acid, one of E. coli most abundant fatty acid (Loiseau et al., 2017). This capacity to bind lipids suggested that UbiJ and UbiK may act as accessory factors of Ubi enzymes, but the role of these two proteins and of UbiB, although central for UQ

show abstract

Untitled

Cited by 3 publications

References 0 publications

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

A Generalized System for Photoresponsive Membrane Rupture in Polymersomes

A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone

Contact Info

Product

Resources

About