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Abstract

The toxicokinetics of pentachlorophenol (PCP) were studied in B6C3F1 mice, a strain in which PCP was previously found to be carcinogenic. In a crossover design, doses of 15 mg/kg were given intravenously (bolus) and orally (gastric intubation) to six animals. Concentrations of PCP in blood, urine, and feces were measured by capillary gas chromatography with electron-capture detection. After intravenous administration, the values of clearance and volume of distribution were 0.057 +/- 0.007 L/hr/kg and 0.43 +/- 0.06 L/kg, respectively. These two parameters exhibited low intermouse variability (coefficients of variation less than 14%). The elimination half-life was 5.2 +/- 0.6 hr. After oral administration, the PCP peak plasma concentration (28 +/- 7 micrograms/ml) occurred at 1.5 +/- 0.5 hr and absorption was complete (bioavailability = 1.06 +/- 0.09). The elimination half-life was 5.8 +/- 0.6 hr. Only 8% of the PCP dose was excreted unchanged by the kidney. PCP was primarily recovered in urine as conjugates. A portion of the dose was recovered in urine as the mutagen, tetrachlorohydroquinone (5%) (TCHQ), and its conjugates (15%). For both PCP and TCHQ, sulfates accounted for 90% or more of the total conjugates (glucuronides and sulfates).

Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis

“…In addition, previous studies have also illustrated the neurotoxic behavior of PCP. , TCBQ is the most toxic in a series of quinones, which has a better capacity of neurotoxicity than HCB and PCP . More than 20% of PCP can be metabolized to TCHQ and TCBQ . In addition, TCBQ was also widely used as a fungicide.…”

Pharmacokinetic Concepts in Assessing Intake of Pentachlorophenol by Rats after Exposure through Drinking Water

“…13 Toxicokinetie Analysis-The program SIPHAR (Simed, Crbteil, France) was used to estimate the toxicokinetic parameters from the individual PCP concentration-time data and to simulate concentration-time profiles.…”

Mechanistic Study on Oxidative DNA Damage and Modifications by Haloquinoid Carcinogenic Intermediates and Disinfection Byproducts

“…The concentrations of PCP were reported to be 0–7.0 μM in body fluids (plasma or urine) of individuals under nonoccupational exposure and 22.5–170 μM in the blood of workers under occupational exposure . Since more than 20% of PCP could be converted to the reactive metabolites TCBQ or TCHQ, the combined level of them is calculated about 0–1.5 μM for nonoccupational exposure and 4.5–34 μM for occupational exposure. The level of 5hmC remarkably increased in cells incubated with TCHQ at 1.0 μM.…”