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Golovanov, I. B.; Tsygankova, I. G.

doi:10.1023/a:1012358813416

Cited by 5 publications

(2 citation statements)

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“…The structure of this channel has never been confirmed by experimental methods. However, many theoretical studies support and use this model 67–74. Moreover, the conformational analysis of AmB membrane channel performed by Silberstein indicates that the stoichiometry proposed originally in the early seventies (i.e., eight AmB molecules per channel) is preferable 72.…”

Section: Current View Of Amb Mechanism Of Actionmentioning

confidence: 99%

AAA award winners

Haines¹

2006

Anat. Rec.

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Section: Current View Of Amb Mechanism Of Actionmentioning

confidence: 99%

AAA award winners

Haines¹

2006

Anat. Rec.

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“…The differences in the boiling points of structurally different isomeric molecules can be explained in terms of correlation between intermolecular interactions with accessible surfaces of the molecules (see [9] and references therein): Assuming that intermolecular interactions are proportional to accessible surfaces of the molecules, we can explain both the increase of the boiling point with increasing n in linear molecules and the decrease of the boiling point of branched molecules compared with linear. However, the above-described concepts fail to explain the fact that cyclic structures have higher boiling points than linear.…”

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confidence: 99%

Quantitative Structure-Property Relationship: XXV. Boiling Points of Aliphatic Monohydric Alcohols. Reasons for the Different Boiling Points of Isomers and Their Compositionally Related Compounds

Golovanov

Zhenodarova

2005

Russ J Gen Chem

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The quantitative structure3property relationship was used to calculate the boiling points of 74 aliphatic monohydric alcohols of various structures; the trends in the properties of isomers and their compositionally related compounds were explained with account for the [hot ends] effect.In [2] we showed that properties of molecules R3X (R is a normal C n H 2n+1 alkyl substituent and X is the residue of an aliphatic or aromatic compound) can be described by a simple equation (1).

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Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance

Mariussen

2012

Arch Toxicol

180

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Perfluoroalkylated compounds (PFCs) are used in fire-fighting foams, treatment of clothes, carpets and leather products, and as lubricants, pesticides, in paints and medicine. Recent developments in chemical analysis have revealed that fluorinated compounds have become ubiquitously spread and are regarded as a potential threats to the environment. Due to the carbon-fluorine bond, which has a very high bond strength, these chemicals are extremely persistent towards degradation and some PFCs have a potential for bioaccumulation in organisms. Of particular concern has been the developmental toxicity of PFOS and PFOA, which has been manifested in rodent studies as high mortality of prenatally exposed newborn rats and mice within 24 h after delivery. The nervous system appears to be one of the most sensitive targets of environmental contaminants. The serious developmental effects of PFCs have lead to the upcoming of studies that have investigated neurotoxic effects of these substances. In this review the major findings of the neurotoxicity of the main PFCs and their suggested mechanisms of action are presented. The neurotoxic effects are discussed in light of other toxic effects of PFCs to indicate the significance of PFCs as neurotoxicants. The main findings are that PFCs may induce neurobehavioral effects, particularly in developmentally exposed animals. The effects are, however, subtle and inconclusive and are often induced at concentrations where other toxic effects also are expected. Mechanistic studies have shown that PFCs may affect the thyroid system, influence the calcium homeostasis, protein kinase C, synaptic plasticity and cellular differentiation. Compared to other environmental toxicants the human blood levels of PFCs are high and of particular concern is that susceptible groups may be exposed to a cocktail of substances that in combination reach harmful concentrations.

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Cited by 5 publications

References 2 publications

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Quantitative Structure-Property Relationship: XXV. Boiling Points of Aliphatic Monohydric Alcohols. Reasons for the Different Boiling Points of Isomers and Their Compositionally Related Compounds

Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance

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