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Cleland, John G.F.; Chattopadhyay, Sudipta; Khand, Aleem; Houghton, Timothy; Kaye, G.

doi:10.1023/a:1020024122726

Cited by 64 publications

(7 citation statements)

References 110 publications

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“…This is demonstrated in our study with about 83% of all victims having heart failure and 57% of those with available echo reports having an EF of <35%. Although being in a better functional class confers lower risk for overall mortality, a larger proportion of death in those with better NYHA class is due to SCD [34]. This is demonstrated in our series with 61% of all victims with heart failure being in NYHA class I and II.…”

Section: Discussionsupporting

confidence: 50%

Sudden Cardiac Death: Clinical Perspectives from the University of Maiduguri Teaching Hospital, Nigeria

Talle¹,

Bonny²,

Bakki³

et al. 2015

WJCD

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Despite tremendous advances in the management of cardiovascular diseases and cardiac arrest, there is paucity of information regarding sudden cardiac death in sub-Saharan Africa. We present a two-year review of sudden cardiac death cases among patients managed at a Nigerian tertiary hospital. Patients admitted from January 2012 to December 2013 were prospectively followed-up and cases of sudden cardiac death identified. Diagnosis was based on records of events preceding death, direct interview of attending physician/nurses, and family members/eye witnesses for out-of-hospital sudden cardiac death. Causes of death were obtained from the death certificates for cases of in-hospital events. Three hundred and eighty eight (M:F = 1:1.3) patients with a mean age of 42.22 ± 19.30 years were admitted into the cardiac unit during the period, out of whom 56 (14.4%) died. Twenty three (41.1%) were classified as sudden cardiac death. The predominant etiology was ischemic cardiomyopathy (39.1%), followed by peripartum cardiomyopathy (21.7%) and dilated cardiomyopathy (17.4%). Rheumatic heart disease was diagnosed in 17.4%, while 4.3% had pulmonary hypertension. Nineteen (82.6%) of the subjects had congestive cardiac failure. Hypokalemia and hypocalcaemia were recorded in 2 (8.7%) patients who developed prolongation of the QT interval following commencement of diuretics. Chest-compression-only cardiopulmonary resuscitation was attempted in 12 (52.1%) with a success rate of 8.3%. Sudden cardiac death is common among our patients admitted with cardiovascular diseases. The most common etiology is ischemic cardiomyopathy, followed by peripartum cardiomyopathy. Most of the victims were young, and there were no optimum resuscitative measures.

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Section: Discussionsupporting

confidence: 50%

Sudden Cardiac Death: Clinical Perspectives from the University of Maiduguri Teaching Hospital, Nigeria

Talle¹,

Bonny²,

Bakki³

et al. 2015

WJCD

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“…Loss of myocyte-fibroblast communication is thought to play a central role in heart disease, especially during end-stage manifestations, which include cardiac fibrosis and arrhythmias. The increased deposition of ECM and fibroblast accumulation in cardiac fibrosis alters myocyte-fibroblast homeostasis as both ECM to myocyte and fibroblast to myocyte ratios are increased [3, 4]. Arrhythmias specifically arise from decoupling of cardiomyocytes, which then leads to conduction slowing, irregular conduction propagation, defects in source-sink activity, and conduction block [5–7].…”

Section: 1 Introductionmentioning

confidence: 99%

“…However, recent in vitro evidence highlights the presence of molecular machinery electrically coupling myocytes to fibroblasts as well as importance of fibroblasts on electrical propagation and conduction of cardiomyocytes, suggesting a potential role in arrhythmias [8]. Thus, a better understanding of myocyte-fibroblast communication is critical in both atrial and ventricular arrhythmias since atrial fibrillation and ventricular tachycardia are the most common causes of cardiac morbidity and sudden cardiac death, respectively [4, 9–11]. Gaps also exist in identifying ideal model systems to decouple or isolate primary defects of how myocyte-fibroblast communication can go awry in these disease processes.…”

Section: 1 Introductionmentioning

confidence: 99%

Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems

Pellman¹,

Zhang²,

Sheikh

2016

Journal of Molecular and Cellular Cardiology

134

103

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Development of cardiac fibrosis and arrhythmias is controlled by the activity of and communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast interactions occur via both direct and indirect means including paracrine mediators, extracellular matrix interactions, electrical modulators, mechanical junctions, and membrane nanotubes. In the diseased heart, cardiomyocyte and fibroblast ratios and activity, and thus myocyte-fibroblast interactions, change and are thought to contribute to the course of disease including development of fibrosis and arrhythmogenic activity. Fibroblasts have a developing role in modulating cardiomyocyte electrical and hypertrophic activity, however gaps in knowledge regarding these interactions still exist. Research in this field has necessitated the development of unique approaches to isolate and control myocyte-fibroblast interactions. Numerous methods for 2D and 3D co-culture systems have been developed, while a growing part of this field is in the use of better tools for in vivo systems including cardiomyocyte and fibroblast specific Cre mouse lines for cell type specific genetic ablation. This review will focus on (i) mechanisms of myocyte-fibroblast communication and their effects on disease features such as cardiac fibrosis and arrhythmias as well as (ii) methods being used and currently developed in this field.

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“…Apart from this question, the items of some tools (GSF-PIG, RADPAC, and SPICT) address mainly patient physical symptoms. These tools may not be able to identify relatively asymptomatic patients with a high risk of dying [87,88]. Therefore, a more comprehensive needs-assessment/ measurement tool like NAT:PD-HF or IPOS would be more appropriate to use in this population.…”

Section: Discussionmentioning

confidence: 99%

Palliative care needs-assessment and measurement tools used in patients with heart failure: a systematic mixed-studies review with narrative synthesis

et al. 2020

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Patients with heart failure have comparable illness burden and palliative care needs to those with cancer. However, few of them are offered timely palliative care. One main barrier is the difficulty in identifying those who require palliative care. Several palliative care needs-assessment/measurement tools were used to help identify these patients and assess/measure their needs, but it is not known which one is the most appropriate for this population. This review aimed to identify the most appropriate palliative care needs-assessment/measurement tools for patients with heart failure. Cochrane Library, MEDLINE Complete, AMED, PsycINFO, CINAHL Complete, EMBASE, EThOS, websites of the identified tools, and references and citations of the included studies were searched from inception to 25 June 2020. Studies were included if they evaluated palliative care needs-assessment/ measurement tools for heart failure populations in terms of development, psychometrics, or palliative care patient/needs identification. Twenty-seven papers were included regarding nineteen studies, most of which were quantitative and observational. Six tools were identified and compared according to their content and context of use, development, psychometrics, and clinical applications in identifying patients with palliative care needs. Despite limited evidence, the Needs Assessment Tool: Progressive Disease-Heart Failure (NAT:PD-HF) is the most appropriate palliative care needs-assessment tool for use in heart failure populations. It covers most of the patient needs and has the best psychometric properties and evidence of identification ability and appropriateness. Psychometric testing of the tools in patients with heart failure and evaluating the tools to identify those with palliative care needs require more investigation.

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Untitled

Cited by 64 publications

References 110 publications

Sudden Cardiac Death: Clinical Perspectives from the University of Maiduguri Teaching Hospital, Nigeria

Sudden Cardiac Death: Clinical Perspectives from the University of Maiduguri Teaching Hospital, Nigeria

Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems

Palliative care needs-assessment and measurement tools used in patients with heart failure: a systematic mixed-studies review with narrative synthesis

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