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Heffer-Lauc, Marija; Čačić, Marko; Šerman, Draško

doi:10.1023/a:1006938221704

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…The c-series gangliosides follow the same pattern as those of the b series. The members of this series with fully extended core (GT1c, GQ1c, GP1c and GH1c) appear in stellate neurons of adult human brain [ 30 ], but are also found in extraneural tissues in species such as rat [ 31 ]. The model predicts the structures of GP1cα, GH1cα and GS1cα, which may correspond to the penta-, hexa-, and septa-sialylated gangliosides observed in embryonic chicken brain [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Simulating the enzymes of ganglioside biosynthesis with Glycologue

McDonald¹,

Davey²

2021

Beilstein J. Org. Chem.

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Gangliosides are an important class of sialylated glycosphingolipids linked to ceramide that are a component of the mammalian cell surface, especially those of the central nervous system, where they function in intercellular recognition and communication. We describe an in silico method for determining the metabolic pathways leading to the most common gangliosides, based on the known enzymes of their biosynthesis. A network of 41 glycolipids is produced by the actions of the 10 enzymes included in the model. The different ganglioside nomenclature systems in common use are compared and a systematic variant of the widely used Svennerholm nomenclature is described. Knockouts of specific enzyme activities are used to simulate congenital defects in ganglioside biosynthesis, and altered ganglioside status in cancer, and the effects on network structure are predicted. The simulator is available at the Glycologue website, https://glycologue.org/.

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Section: Resultsmentioning

confidence: 99%

Simulating the enzymes of ganglioside biosynthesis with Glycologue

McDonald¹,

Davey²

2021

Beilstein J. Org. Chem.

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“…However, c-series gangliosides and their O-acetyl derivatives are temporarily expressed in embryonic stages in the CNS but seldom during adulthood in vertebrates [66–70]. Cerebellar stellate neurons are the only known exception in the adult human CNS that express c-series gangliosides [71]. This raises the question whether remyelination-promotion in adult mice by A2B5 is mediated through binding to SLs or glycoproteins [47].…”

Section: Natural Antibodiesmentioning

confidence: 99%

Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire

Watzlawik

Wootla

Painter

et al. 2013

Expert Review of Neurotherapeutics

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Immunoglobulins with germline sequences occur in invertebrates and vertebrates and are named naturally occurring autoantibodies (NAbs). NAbs may target foreign antigens, self- or altered self-components and are part of the normal immunoglobulin repertoire. Accumulating evidence indicates that naturally occurring antibodies can act as systemic surveillance molecules, which tag, damaged or stressed cells, invading pathogens and toxic cellular debris for elimination by the immune system. In addition to acting as detecting molecules, certain types of NAbs actively signal in different cell types with a broad range of responses from induction of apoptosis in cancer cells to stimulation of remyelination in glial cells. This review emphasizes functions and characteristics of NAbs with focus on remyelination-promoting mouse and human antibodies. Human remyelination-promoting NAbs are potential therapeutics to combat a wide spectrum of disease processes including demyelinating diseases like multiple sclerosis. We will highlight the identified glycosphingolipid (SL) antigens of polyreactive remyelination-promoting antibodies and their proposed mechanism(s) of action. The nature of the identified antigens suggests a lipid raft-based mechanism for remyelination-promoting antibodies with SLs as most essential raft components. However, accumulating evidence also suggests involvement of other antigens in stimulation of remyelination, which will be discussed in the text.

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Immunostaining of ganglioside GD1b, GD3 and GM1 in rat cerebellum: Cellular layer and cell type specific associations

et al. 2000

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We have studied the cellular distribution of gangliosides GD1b, GD3 and GM1 in rat cerebellum by immunostaining, using monoclonal antibodies and confocal microscopy. Antibodies against astroglial, neuronal and synaptic vesicle associated molecules were used for colocalization analyses. In the gray matter, the anti-GD1b antibody stained thin strands in the molecular layer (ML), interpreted as Bergman glia fibers based on colocalized staining with anti-glial fibrillary acidic protein (GFAP). The neuropil in the granule (GL) and Purkinje (PL) cell layers was also anti-GD1b positive. The anti-GD3 antibody stained the ML, the neuropil in the GL and PL and also the granule and Purkinje cell bodies, appearing intracytoplasmically and vesicle associated. Anti-GD1b and anti-GD3 staining in the GL glomeruli were colocalized with anti-synaptophysin staining. The anti-GM1 antibody stained cell bodies in the ML but they could not be characterized in colocalization experiments. The GL and PL were not stained with the anti-GM1 antibody. In the white matter, different staining patterns were seen for the gangliosides, the anti-GM1 staining being the most intense. This study shows cellular layer and cell type specific associations of the investigated gangliosides and localization of GD1b and GD3 at synaptic sites, warranting further studies on their role in synaptic mechanisms.

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Untitled

Cited by 10 publications

References 14 publications

Simulating the enzymes of ganglioside biosynthesis with Glycologue

Simulating the enzymes of ganglioside biosynthesis with Glycologue

Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire

Immunostaining of ganglioside GD1b, GD3 and GM1 in rat cerebellum: Cellular layer and cell type specific associations

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