99Tcm-MIBI mammoscintigraphy of breast masses: Early and delayed imaging

Lu, G.; Shih, Wei-Jen; Huang, Huaigu; LONG, M.-Q.; Sun, Qing; LIU, Y.-H.; Chou, Cecilia

doi:10.1097/00006231-199516030-00007

Cited by 36 publications

(9 citation statements)

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“…They assumed that the radiopharmaceutical uptake by malignant tumors might persist on delayed images in contrast to that of benign lesions, which would fade away. Similar to our results, Lu et al [24] found that the delayed image was not benefi cial in the diagnosis of breast cancer.…”

Section: Discussionsupporting

confidence: 92%

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Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

et al. 2007

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The aim of the study was to compare the diagnostic performances of visual and quantitative analyses of double-phase Tc-99m methoxyisobutylisonitrile (MIBI) scintimammography (SMM) in patients with ultrasonographically indeterminate findings. SMM (early: 10min; delayed: 3h) was performed on 78 patients (malignant 66, benign 12). For visual analysis, the five-scoring method was used. For quantitative analysis, ratios of early and delayed lesions to non-lesion (L/Ns) were calculated. When a visual grade of over 3 was used as the cut-off value for the detection of primary breast cancer, the sensitivity and specificity were 86.4%/ and 100%, respectively. The area under the curve (AUC) was 0.972. The optimal L/N ratios were 1.22 for early and 1.1 for delayed images. When early L/N 1.22 was used as the cut-off point, the sensitivity and specificity of SMM were 92.4% and 91.7'%, respectively. The AUC was 0.952. When delayed L/N 1.1 was used as the cut-off value, the sensitivity and specificity were 78.8% and 91.7%, respectively. The AUC was 0.863. Visual interpretation and early L/N were superior to delayed L/N for the detection of breast cancer. This study suggests the possible diagnostic role of visual and quantitative analyses of double-phase SMM for differentiating malignant breast lesions in patients with ultrasonographi-cally indeterminate findings.

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Section: Discussionsupporting

confidence: 92%

“…Some previous studies have used double-phase SMM for the diagnosis of primary breast cancer [23][24][25][26]. In all these studies, the reason for performing double-phase SMM early and delayed imaging was to differentiate between benign and malignant diseases more accurately.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

et al. 2007

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“…in contrast to uptake by benign lesions, which would fade away. Similar to our results, LU et al (14) found that the delayed image was not beneficial in the diagnosis of breast cancer and concluded that SMM should be performed within 30 min after injection of the radiopharmaceutical.…”

Section: Discussionsupporting

confidence: 91%

Comparison of early and delayed quantified indices of double‐phase ^99mtc mibi scintimammography in the detection of primary breast cancer

Kim

Bae

et al. 2005

Acta Radiol

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From this study, the optimal visual grades for diagnosis of breast cancer were grades 4 and 5; the cut-off values of L/Ns were 1.27 for early and 1.12 for delayed imaging. It was also found that early L/Ns provide incremental value in addition to visual analysis. However, delayed L/N revealed no incremental value. Therefore, the delayed image should not be routinely performed for purposes of primary breast cancer detection

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“…However few anecdotal reports indicate an improved target-to-background ratio by starting the data acquisition 60-90 min after injection of the tracer [82]. Despite these data, it is currently recognized that high diagnostic accuracy can be achieved by starting imaging 5-15 min after injection of 99m Tc-sestamibi, which is in accordance to the time line recommended by both the EANM as well as the SNM.…”

Section: Image Acquisitionmentioning

confidence: 98%

99mTc-Sestamibi Scintimammography

Bucerius

2011

99mTc-Sestamibi

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From an anatomical point of view, the mammary gland is part of the female secondary sexual characteristics. The primary biological function of the mammary glands is the feeding of infants with breast milk. The mammary glands belong to the major glands of the cutis (glandulae cutis) and develop from epithelial cones, which grow in the surrounding connective tissue. Initially, the mammary glands are established in the same way in both genders.The female mammary glands are located on the major and minor pectoral muscles (M. pectoralis major, M. pectoralis minor) between the third and the seventh rib and between the sternal-and axillary line. The arterial blood supply of the mammary glands is provided by vascular branches (R. mammarii mediales and laterales) of the internal and lateral thoracic arteries (A. thoracica interna, A. thoracica lateralis) as well as by branches (R. preforantes and R. mammarii laterales) of the anterior and posterior intercostal arteries (Aa. intercostales anterior and posterior). The venous drain follows from superficial veins into the lateral and internal thoracic veins (Vv. thoracica lateralis and interna). The mammary glands are characterized by numerous lymphatic vessels, which build a superficial and deep lymphatic mesh with several directions of lymphatic drainage. From a clinical point of view, the main and most important lymphatic drainage reaches the axillary lymph nodes. Additional lymphatic drains flow off to the cervical lymph nodes superior to the clavicles and via the interpectoral lymphatic nodes (N. lymphatici interpectorales) between the pectoral muscles to the axillary lymph nodes, via the parasternal lymph nodes (N. lymphatici parasternales) along the internal thorac vein, and via the

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99Tcm-MIBI mammoscintigraphy of breast masses: Early and delayed imaging

Cited by 36 publications

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Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

Comparison of early and delayed quantified indices of double‐phase ^99mtc mibi scintimammography in the detection of primary breast cancer

99mTc-Sestamibi Scintimammography

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99Tcm-MIBI mammoscintigraphy of breast masses: Early and delayed imaging

Cited by 36 publications

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Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

Comparison of early and delayed quantified indices of double‐phase 99mtc mibi scintimammography in the detection of primary breast cancer

99mTc-Sestamibi Scintimammography

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Comparison of early and delayed quantified indices of double‐phase ^99mtc mibi scintimammography in the detection of primary breast cancer