99mTc-plasmin test in deep vein thrombosis of the leg

Aronen, H; Korppi-Tommola, T; Suoranta, H; Taavitsainen, M.

doi:10.1007/bf00261755

Eur J Nucl Med

1985

DOI: 10.1007/bf00261755

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99mTc-plasmin test in deep vein thrombosis of the leg

H Aronen

T Korppi-Tommola

H Suoranta

et al.

Abstract: A 99mTc-plasmin test and phlebography were performed on 45 consecutive unselected patients with suspected deep vein thrombosis of the leg. Phlebography showed thrombosis in 15 cases. In fourteen of these patients there was a positive result in the plasmin test. Eleven other patients had a positive plasmin test result as well. The most common causes for a false-positive result in the plasmin test in the diagnosis of deep vein thrombosis were acute inflammatory disease and disturbance in venous flow without fres… Show more

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Cited by 4 publications

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“…The '*'Ifibrinogen test can only show a developing thrombus (1 1). The ?cm-plasmin test is sensitive and rapid but lacks specifcity for the thrombus (1, 3).…”

mentioning

confidence: 99%

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Aronen¹

1989

Acta Radiol

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Fourteen unselected consecutive patients with clinically suggested deep venous thrombosis were studied using "'In-labelled monoclonal antibody Fab-fragments (59D8) in order to evaluate the accuracy of antifibrin imaging. Scintigrams of the legs were obtained at 1 to 4 h and 20 to 28 h in all patients and in seven dynamic studies were also performed. Contrast medium phlebography used as diagnostic standard revealed thrombosis in six patients who also had increased uptake of the tracer at immunoscintigraphy. Three patients had a positive finding at immunoscintigraphy without thrombosis. Because of the high sensitivity of this method, normal antifibrin images may be used to exclude thrombosis. Phlebography may then be restricted to positive cases to confirm the presence of thrombosis.

show abstract

“…The '*'Ifibrinogen test can only show a developing thrombus (1 1). The ?cm-plasmin test is sensitive and rapid but lacks specifcity for the thrombus (1, 3).…”

mentioning

confidence: 99%

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Aronen¹

1989

Acta Radiol

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Return to normal of 99mTc-plasmin test after deep venous thrombosis and its relationship to vessel wall fibrinolysis

et al. 1986

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Fourteen patients with deep venous thrombosis (DVT) and a positive 99mTc-plasmin test were followed up to determine how soon a negative test was obtained. Localization and extension of the thrombi were determined by phlebography. Plasminogen activator activity in vein walls and local fibrinolytic activity after venous occlusion were measured in order to find out what the prerequisites for impaired thrombolysis are. The time required to obtain a negative 99mTc-plasmin test showed considerable variation, ranging from less than 1 week to more than 6 months. The 99mTc-plasmin test had returned to normal in 64% of the patients after 6 months. No relationship was found between vessel wall fibrinolysis and time to normalization. Instead, we found an association between the time to normalization of the 99mTc-plasmin test and the size of the thrombus, according to phlebography, as well as between the time to normalization of the 99mTc-plasmin test and the extension of leg points with a positive 99mTc-plasmin test at admission. The finding of abnormal 99mTc-plasmin test results more than 6 months after acute DVT is of practical importance and warrants caution when evaluating patients with symptoms and signs suggestive of acute recurrent DVT.

show abstract

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Aronen

1989

Acta Radiol

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Fourteen unselected consecutive patients with clinically suggested deep venous thrombosis were studied using 111In-labelled monoclonal antibody Fab-fragments (59D8) in order to evaluate the accuracy of antifibrin imaging. Scintigrams of the legs were obtained at 1 to 4 h and 20 to 28 h in all patients and in seven dynamic studies were also performed. Contrast medium phlebography used as diagnostic standard revealed thrombosis in six patients who also had increased uptake of the tracer at immunoscintigraphy. Three patients had a positive finding at immunoscintigraphy without thrombosis. Because of the high sensitivity of this method, normal antifibrin images may be used to exclude thrombosis. Phlebography may then be restricted to positive cases to confirm the presence of thrombosis.

show abstract

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99mTc-plasmin test in deep vein thrombosis of the leg

Cited by 4 publications

References 12 publications

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Return to normal of 99mTc-plasmin test after deep venous thrombosis and its relationship to vessel wall fibrinolysis

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

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99mTc-plasmin test in deep vein thrombosis of the leg

Cited by 4 publications

References 12 publications

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with111In-Labelled Monoclonal Antifibrin Antibody Fragments

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with111In-Labelled Monoclonal Antifibrin Antibody Fragments

Return to normal of 99mTc-plasmin test after deep venous thrombosis and its relationship to vessel wall fibrinolysis

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with111In-Labelled Monoclonal Antifibrin Antibody Fragments

Contact Info

Product

Resources

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Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments

Diagnosis of Deep Venous Thrombosis of the Leg Using Immunoscintigraphy with¹¹¹In-Labelled Monoclonal Antifibrin Antibody Fragments