99mTc-MIBI imaging in thyroid nodules: Is it useful?

Abstract

Treglia et al. [1] have recently proposed a meta-analysis evaluating the diagnostic performance of 99mTc-MIBI scan in predicting the malignancy of thyroid nodules.99m-Tc is registered and adopted worldwide for myocardial perfusion imaging and for the diagnostic work-up of hyperparathyroidism. Furthermore there are reports on the use of 99mTc-MIBI imaging in post-surgical evaluation of thyroid cancer, for residual tumor localization, especially when the 131I-Na whole-body scan is negative with detectable values of thyroglobulin [2]. However, this indication has been almost completely replaced by 18F-FDG PET/CT imaging [3].Treglia and colleagues reported the results of 21 studies, accurately selected by rigorous methodology out of 690 articles. The 21 pooled studies included nearly two thousand patients. They have demonstrated that the 99mTc-MIBI scintigraphy has good sensitivity, although suboptimal specificity, in predicting histological malignancy of thyroid nodules. These results offer a solid background for considering the clinical usefulness of 99mTc-MIBI imaging in a clinical setting.No indications to perform a 99mTc-MIBI scintigraphy are reported in guidelines or algorithms of diagnostic workup of thyroid nodules [4], that is mainly based on the wide use of ultrasounds and cytology after echo-guided fineneedle aspiration (FNA).The question that the paper of Treglia rises is related to the additional value, if any, of molecular imaging by 99mTc-MIBI over the traditional, standardized patient work-up.FNA is frequently inconclusive when Class 3 follicularpatterned lesions are detected, including follicular neoplasms, Hürthle cell lesions, and the follicular variant of PTC. In centers with specific experience in thyroid cytology, follicular cytologic findings may be further subdivided into ''follicular lesion/atypia of undetermined significance'' and ''follicular neoplasm.'' This distinction separates two cytologic groups at different risks for thyroid malignancy but with the same operative indications [4]. Preliminary data seem to demonstrate that (99m)Tc-MIBI scintigraphy is an adjunctive method to predict preoperatively the malignant behavior of nononcocytic follicular thyroid nodules indeterminate at FNA biopsy [5], whereas it does not show same accuracy in Hürthle cell tumors [6,7]. Further, multicenter studies are required to accept this hypothesis. This is a crucial point in the diagnosis of thyroid nodules as other techniques fail to offer meaningful results. In a recent study aimed to determine the rate of malignancy and the ultrasonographic features that could be used as predictor of malignant pathologies at the nodules with indeterminate cytology, Tutuncu et al. [8] have seen that ultrasound is not accurate enough to exclude malignancy in this high-risk population. Our group has recently analyzed the clinical significance of thyroid focal uptake of 18F-FDG in patients who underwent PET/CT for nonthyroid diseases [9]. Two hundred and eleven patients (28.9 %) underwent further investigation to determi...