99mTc-labeling and molecular modeling of short dipeptide glycyl-l-proline

Staník, R.; Benkovský, I.

doi:10.1007/s10967-010-0852-6

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Determination of the exact structure and composition of the reaction product of 99m Tc-TMPP complex is impossible because the amount of 99m Tc eluted from 99 Mo/ 99m Tc generator is very little ca. 10-9 mol/L (Stanik and Benkovsky, 2011). Thus, we use theoretical background and methods of molecular modeling to suggest and purpose 99m Tc-TMPP complex.…”

Section: Molecular Geometrymentioning

confidence: 99%

Preparation and biological evaluation of 99mTc-TMPP as a novel agent for tumor diagnosis

Abdel‐Aziz

Elsabagh

Motaleb

2015

Zagazig Journal of Pharmaceutical Sciences

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Compound 5, 10, 15, 20 tetrakis {4-methoxyphenyl} 21H, 23H porphyrin (TMPP) was labeled with technetium-99m via direct labeling technique using stannous chloride as a reducing agent. The optimum conditions that gave high labeling yield (95.2%) of 99m Tc-TMPP complex were achieved by using 3mg TMPP, 100µg SnCl 2 .2H 2 O, at pH 3 and 30min reaction time. Molecular geometry was used to illustrate the structure of complex which is formed between 99m Tc and TMPP. The preclinical evaluation and biodistribution in solid tumor bearing mice showed high biological accumulation in solid tumor cells (22.66 % injected activity/ g tissue) and high T/NT ratio equal to 3.21 ± 0.15 at 30 minutes post-injection. Data described before could recommend 99m Tc-TMPP as a potential targeting radiopharmaceutical for tumor imaging.

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Section: Molecular Geometrymentioning

confidence: 99%