99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer's type ? a study under clinical routine conditions

Stoppe, Gabriela; Staedt, J.; Kögler, Andreas; Schütze, R; Kunert, Hanns Jürgen; Sandrock, D.; Munz, Dieter L.; Emrich, D.; Rüther, Eckart

doi:10.1007/bf01271479

Cited by 17 publications

(6 citation statements)

References 63 publications

(35 reference statements)

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“…Posterior cortical rCBF deficits are considered pathognomonic of resting state scans in AD. However, frontal lobe hypoperfusion has been noted as a prominent feature in some studies 7,10 , 12–23 …”

Section: Discussionmentioning

confidence: 99%

“…However, frontal lobe hypoperfusion has been noted as a prominent feature in some studies. 7,10,[12][13][14][15][16][17][18][19][20][21][22][23] A number of possible explanations for prefrontal rCBF deficits in our AD subjects were considered. It is possible that a differential effect of the cognitive component of the task on rCBF in AD subjects and healthy controls may have produced this effect.…”

Section: Comparison Of Regional Cerebral Blood Flow Between Groupsmentioning

confidence: 99%

“…Frontal hypoperfusion has been noted as a prominent feature in many studies of AD 7,10 , 12–23 . A few studies have quantified the proportion of AD subjects showing frontal rCBF deficits.…”

Section: Introductionmentioning

confidence: 99%

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Regional cerebral blood flow deficits in mild Alzheimer's disease using high resolution single photon emission computerized tomography

Trollor

Sachdev

Haindl

et al. 2005

Psychiatry Clin Neurosci

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In spite of its wide availability, single photon emission computerized tomography (SPECT) scanning is uncommonly used in the assessment of Alzheimer's disease (AD) and related dementias. In light of recent advances in scanning protocols and image analysis, SPECT needs to be re-examined as a tool in the diagnosis of dementia. A total of 18 subjects with early AD and 10 healthy elderly control subjects were examined with high resolution SPECT during the performance of a simple word discrimination task. SPECT images were coregistered with individual magnetic resonance imaging scans, allowing delineation of predetermined neuroanatomical Regions of Interest (ROI).There was a gradation of regional cerebral blood flow (rCBF) values in both groups, with the lowest values being in the hippocampus and the highest in the striatum, thalamus and cerebellum. Compared to healthy controls, AD subjects demonstrated lower relative rCBF in parietal and prefrontal cortices. Analysis of individual ROI demonstrated bilateral reduction of rCBF in prefrontal poles, posterior temporal and anterior parietal cortex, and unilateral reduction of rCBF in left dorsolateral prefrontal cortex, right posterior parietal cortex and the left cingulate body. There were no significant differences for hippocampal, occipital or basal ganglia rCBF. Discriminant function analysis indicated that rCBF in the prefrontal polar regions achieved the best classification of cases. SPECT has utility in the diagnostic assessment of AD if standardized and semiquantitative techniques are used.

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Section: Discussionmentioning

confidence: 99%

Section: Comparison Of Regional Cerebral Blood Flow Between Groupsmentioning

confidence: 99%

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Regional cerebral blood flow deficits in mild Alzheimer's disease using high resolution single photon emission computerized tomography

Trollor

Sachdev

Haindl

et al. 2005

Psychiatry Clin Neurosci

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“…However, this procedure did not reveal significant differences, either. Stoppe et al (1995) defined the individual perfusion deficit patterns as the cortical region with the lowest corticocerebellar ratio. Compared to depressed patients only parieto-occipital perfusion deficits were specific for patients with Alzheimer's disease.…”

Section: Variability Of Perfusion Deficit Patternsmentioning

confidence: 99%

Variability of cerebral blood fow deficits in99mTc-HMPAO SPECT in patients with Alzheimer's disease

Zimmer

Leucht

Rädler

et al. 1997

J. Neural Transmission

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The purpose of this study was to analyse the frequency of the different pathological perfusion patterns in SPECT in a clinical, unselected population of patients with Alzheimer's disease. In 91 patients and 16 control subjects regional cerebral blood flow (rCBF) was measured with Single Photon Emission Computed Tomography (SPECT) using 99mTc-hexa-methyl-propyleneamine oxime (HMPAO). 95% confidence intervals obtained from the perfusion values of the control subjects were used to define normal perfusion ranges. The frequency of perfusion deficits in the left frontal, temporal, parietal and occipital lobes were 62.2%, 60.4%. 70.3% and 23.1%, respectively. In the right hemisphere the corresponding values were 60.4%, 58.2%, 63.7% and 9.9%. With the exception of the occipital lobes these frequencies were not significantly different. The analysis of the perfusion pattern of each patient revealed 35 different combinations of lobes with perfusion deficits. The temporo-parietal perfusion deficits were not more frequent than the temporofrontal perfusion deficits. These results suggest that in the clinical routine a high variety of heterogeneous rCBF patterns have to be expected.

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“…In discriminating the patients with AD from those with non-dementia by SPECT using 99m Tc-HMPAO, a sensitivity of 48-91% and a specifi city of 64-94% have been shown [17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Alzheimer’s disease with vascular dementia and non-dementia using specific voxel-based Z score maps

Ishii¹,

Shishido²,

Miyajima³

et al. 2009

Ann Nucl Med

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99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer's type ? a study under clinical routine conditions

Cited by 17 publications

References 63 publications

Regional cerebral blood flow deficits in mild Alzheimer's disease using high resolution single photon emission computerized tomography

Regional cerebral blood flow deficits in mild Alzheimer's disease using high resolution single photon emission computerized tomography

Variability of cerebral blood fow deficits in99mTc-HMPAO SPECT in patients with Alzheimer's disease

Comparison of Alzheimer’s disease with vascular dementia and non-dementia using specific voxel-based Z score maps

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