99mTc-HMPAO labelled leucocyte scintigraphy in the diagnosis of pelvic inflammatory disease

Abstract

We showed that scintigraphy with 99mTc-HMPAO labelled leucocytes had a sensitivity of 100%, specificity of 90%, overall accuracy of 93%, positive predictive value of 83%, and negative predictive value of 100%. Therefore, we conclude that 99mTc-HMPAO labelled leucocyte scans provide a rapid and highly accurate method for diagnosing pelvic inflammatory disease in women of child-bearing age. This adds an important contribution to the diagnosis of infection and helps determine further operative or conservative treatment.

The Labeled-Leukocyte Scan in the Study of Abdominal Abscesses

“…In another study of 15 females suspected of having pyogenic pelvic inflammatory disease, there was no false negative result but one false positive result obtained with LS. The scan accurately reflected the absence of pelvic inflammatory disease in nine patients (negative predictive value of 100%), showing nonpathological tracer uptake in the lower abdominal region [38]. Similar results were obtained with the same pelvic pathology by other authors [33,42].…”

“…In the last 30 years, a large number of papers have reported satisfactory results on the use of LS in the diagnosis of abdominal abscess, the most relevant of which are reported in Table 1 [25][26][27][28][29][30][31][32][33][34][35][36][37][38]. This diagnostic tool is sensitive in detecting abdominal abscess in different locations except for the liver and spleen due to physiological localization of labeled cells in these organs [39].…”

Intracellular Localization of ^99mTc-<i>d,l</i>-HMPAO in Rat Blood

“…99m Tc-d,l -HMPAO is thought to accumulate in the brain through its intracellular conversion from a lipophilic to a hydrophilic form within the brain parenchyma [2][3][4] . In addition, it has been used to label leukocytes for detection of inflammation [5] . Cell labeling can provide information of clinical importance, which depends on the uptake and/or the intracellular localization of Tc generator (GE Healthcare).…”