99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats

Murphy, Consuelo Arteaga de; Ferro-Flores, Guillermina; Villanueva-Sanchez, Octavio; Murphy-Stack, Eduardo; Pedraza-López, Martha; Meléndez‐Alafort, Laura; Molina-Trinidad, Eva María

doi:10.1016/s0378-5173(01)00922-x

Cited by 17 publications

(7 citation statements)

References 7 publications

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“…After coronary artery ligation, the ECG and pathological findings were corresponding, most of which were extensive anterior wall MI and showed good reproducibility and stability [32]. Currently, it is the most recognized and commonly used model of MI; however, establishment of this animal model needs high proficiency; (2) coronary artery stenosis or occlusion is caused by intravenous injection of vasoconstrictor drugs [33]. The establishing procedure of this method is simple, mainly diffuse myocardial injury in the whole heart, rather than the local myocardial injury.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 for Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms

Zheng

Bao

Zhu

et al. 2017

Oxidative Medicine and Cellular Longevity

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Ginseng is an important herbal drug that has been used worldwide for many years. Ginsenoside Rb1 (G-Rb1), the major pharmacological extract from ginseng, possesses a variety of biological activities in the cardiovascular systems. Here, we conducted a preclinical systematic review to investigate the efficacy of G-Rb1 for animal models of myocardial ischemia/reperfusion injury and its possible mechanisms. Ten studies involving 211 animals were identified by searching 6 databases from inception to May 2017. The methodological quality was assessed by using the CAMARADES 10-item checklist. All the data were analyzed using RevMan 5.3 software. As a result, the score of study quality ranged from 3 to 7 points. Meta-analyses showed that G-Rb1 can significantly decrease the myocardial infarct size and cardiac enzymes (including lactate dehydrogenase, creatine kinase, and creatine kinase-MB) when compared with control group (P < 0.01). Significant decrease in cardiac troponin T and improvement in the degree of ST-segment depression were reported in one study (P < 0.05). Additionally, the possible mechanisms of G-Rb1 for myocardial infarction are antioxidant, anti-inflammatory, antiapoptosis, promoting angiogenesis and improving the circulation. Thus, G-Rb1 is a potential cardioprotective candidate for further clinical trials of myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 for Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms

Zheng

Bao

Zhu

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Signal et al induced myocardial ischemia in rats with isoproterenol (a synthetic -adrenergic agonist) [39]. Similarly, Chagoya et al developed a rat MI model by utilising isoproterenol [40]; and Arteaga de Murphy and his group successfully duplicated the MI model in rats with a subcutaneous injection of isoproterenol [41]. While, Arnolde et al created an ischemia model in rabbits by the intraperitoneal injection of adriamycin [42].…”

Section: Pharmacologically-induced Modelmentioning

confidence: 99%

Animal Models of Cardiac Disease and Stem Cell Therapy

Liu³

et al. 2010

TOCMJ

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Animal models that mimic cardiovascular diseases are indispensable tools for understanding the mechanisms underlying the diseases at the cellular and molecular level. This review focuses on various methods in preclinical research to create small animal models of cardiac diseases, such as myocardial infarction, dilated cardiomyopathy, heart failure, myocarditis and cardiac hypertrophy, and the related stem cell treatment for these diseases.

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“…Subcutaneous (sc) injection of ISO at 67 mg/kg in rats is known to produce histologically detectable MI within 24 hours. 34 In preliminary tests, we observed that using higher doses of ISO, such as 85 mg/kg and above, resulted in high mortality rates in our rats.…”

Section: Animal Procedures and Experimental Protocolmentioning

confidence: 72%

Lack of cardioprotection by single-dose magnesium prophylaxis on isoprenaline-induced myocardial infarction in adult Wistar rats

Garson

Kelly-Laubscher

Blackhurst

et al. 2015

CVJA

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SummaryAimMagnesium (Mg2+) is effective in treating cardiovascular disorders such as arrhythmias and pre-eclampsia, but its role during myocardial infarction (MI) remains uncertain. In this study, we investigated the effects of Mg2+ pre-treatment on isoprenaline (ISO)-induced MI in vivo.MethodsRats divided into four groups were each pre-treated with either MgSO4 (270 mg/kg intraperitoneally) or an equivalent volume of physiological saline, prior to the ISO (67 mg/kg subcutaneously) or saline treatments. One day post-treatment, the electrocardiogram and left ventricular blood pressures were recorded. Infarcts were determined using 2,3,5-triphenyltetrazolium chloride staining, and serum markers of lipid peroxidation were measured with spectrophotometric assays.ResultsMg2+ pre-treatment neither altered the ISO-induced infarct size compared with ISO treatment alone (p > 0.05), nor reversed the low-voltage electrocardiogram or the prominent Q waves induced by ISO, despite a trend to decreased Q waves. Similarly, Mg2+ did not prevent the ISO-induced decrease in peak left ventricular blood pressure or the decrease in minimal rate of pressure change. Mg2+ did not reverse the ISO-induced gain in heart weight or loss of body weight. Neither ISO nor Mg2+ altered the concentrations of lipid peroxidation markers 24 hours post MI induction.ConclusionAlthough Mg2+ had no detrimental effects on electrical or haemodynamic activity in ISO-induced MI, the lack of infarct prevention may detract from its utility in MI therapy.

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99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats

Cited by 17 publications

References 7 publications

Ginsenoside Rb1 for Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms

Ginsenoside Rb1 for Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms

Animal Models of Cardiac Disease and Stem Cell Therapy

Lack of cardioprotection by single-dose magnesium prophylaxis on isoprenaline-induced myocardial infarction in adult Wistar rats

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