99mTc-DADT complexes substituted with heterocyclic amines: Effect of substitution on in vivo reactivity

Papadopoulos, Minas; Stathaki, S.; Mastrostamatis, S.; Varvarigou, Alexandra D.; Chiotellis, E.

doi:10.1016/0969-8051(93)90143-i

Cited by 9 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance [119], the alkaline hydrolysis of 2-amino-5-methyl-4-nitrobenzothiazole afforded 2-amino-5-methyl-3-nitrophenol. The ring opening of 3,3,6,6,10,10-hexamethyl-1,2-dithia-5,8-diazacyclodecane under the action of monochloroacetic anhydride was described [120]. The arising intermediate product was reduced into a dithiol by LiAlH 4 .…”

Section: Thiol Synthesis By Reduction Of Organosulfur Compoundsmentioning

confidence: 99%

Synthesis, Structure, and Physicochemical Characteristics of Thiols

Koval

2005

Russ J Org Chem

View full text Add to dashboard Cite

Section: Thiol Synthesis By Reduction Of Organosulfur Compoundsmentioning

confidence: 99%

Synthesis, Structure, and Physicochemical Characteristics of Thiols

Koval

2005

Russ J Org Chem

View full text Add to dashboard Cite

“…Various BFCs (Figure 2), including MAG 2 /MAG 3 [23], HYNIC (6‐hydrazinonicotinic acid) [24], DADT [25], EC [26], and N 3 S [27], have been developed for peptide radiolabeling. Another approach is the use of organometallic 99m Tc tricarbonyl complexes, which offer high stability and specific activity [28].…”

Section: Technetium‐99m and Radiolabelingmentioning

confidence: 99%

Clinical application of ^99mTc‐labeled peptides for tumor imaging: Current status and future directions

Shi,

Liu

2024

iRADIOLOGY

View full text Add to dashboard Cite

Targeting receptors overexpressed on cancer cells with radiolabeled peptides has become a crucial aspect of molecular imaging in oncology. Small peptides offer favorable characteristics for tumor targeting with minimal side effects and toxicity owing to their small size and simple radiolabeling protocols. Among them, somatostatin analogs have received regulatory approval for the diagnosis and treatment of neuroendocrine tumors. Cyclic RGD (Arg‐Gly‐Asp) peptides, bombesin analogs, and glucagon‐like peptide‐1 analogs are currently under development and/or undergoing clinical trials. The most used radionuclides for tumor imaging include 99mTc and 111In for single‐photon emission computed tomography, 68Ga and 18F for positron emission tomography. This review highlights the clinical potential and future prospects of 99mTc‐labeled peptides for tumor imaging.

show abstract

“…A previous study [14] showed that this type of substitution led to pharmacologically active 99mTc complexes. Animal studies of the investigated aminothiols (compounds 7 10) revealed that the sustituents introduced in DADT backbone also influenced, greatly the in vivo behaviour of the respective indium chelates.…”

Section: Fig 1 Ligands Investigated In the Present Study Synthesismentioning

confidence: 99%

Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation

et al. 1993

Self Cite

View full text Add to dashboard Cite

In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. A system of one six-membered and two five-membered rings, formed by the metal and the donor atoms of the ligand, may constitute a basic structure for the development of new indium tracers with myocardial affinity.

show abstract

99mTc-DADT complexes substituted with heterocyclic amines: Effect of substitution on in vivo reactivity

Cited by 9 publications

References 7 publications

Synthesis, Structure, and Physicochemical Characteristics of Thiols

Synthesis, Structure, and Physicochemical Characteristics of Thiols

Clinical application of ^99mTc‐labeled peptides for tumor imaging: Current status and future directions

Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation

Contact Info

Product

Resources

About

99mTc-DADT complexes substituted with heterocyclic amines: Effect of substitution on in vivo reactivity

Cited by 9 publications

References 7 publications

Synthesis, Structure, and Physicochemical Characteristics of Thiols

Synthesis, Structure, and Physicochemical Characteristics of Thiols

Clinical application of 99mTc‐labeled peptides for tumor imaging: Current status and future directions

Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation

Contact Info

Product

Resources

About

Clinical application of ^99mTc‐labeled peptides for tumor imaging: Current status and future directions