99mTc(CO)3-VIP analogues: Preparation and evaluation as tumor imaging agent

Kothari, Kanchan; Prasad, S.; Korde, Aruna; Mukherjee, Archana; Mathur, Archana; Jaggi, Manu; Venkatesh, Meera; Pillai, Ambikalmajan M.R.; Mukherjee, Rama; Ramamoorthy, N.

doi:10.1016/j.apradiso.2006.11.001

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…As an example, the synthesis of a series of M(CO) 3 -based (M = Re, Tc) Carbonic Anhydrase IX inhibitors was developed using Re(CO) 3 , while the affinity for CA-IX was evaluated using the final 99m Tc complexes [77]. Peptides were also labelled with Re/Tc tricarbonyl complexes, generally in order to target specific cell lines or events [86][87][88][89]. In most of these examples, the rhenium is used for its reactivity close to the technetium and for the similarities of the Re and Tc complexes.…”

Section: Re(co) 3 As Surrogates For 99mmentioning

confidence: 99%

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Hostachy

Policar

Delsuc

2017

Coordination Chemistry Reviews

112

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Bio-imaging, by enabling the visualization of biomolecules of interest, has proved to be highly informative in the study of biological processes. Although fluorescence microscopy is probably one of the most used techniques, alternative methods of imaging, providing complementary information, are emerging. In this context, metal complexes represent valuable platforms for multimodal imaging, since they may combine interesting spectroscopic features and biologically relevant functionalization on a single molecular core. In particular, d6 low-spin rhenium tri-carbonyl complexes display unique luminescence and vibrational properties, and can be readily functionalized. Here we review their applications and potential as probes or drugs relying on their photophysical properties, before focusing on their use as multimodal probes for the labelling and imaging of peptides and proteins.

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Section: Re(co) 3 As Surrogates For 99mmentioning

confidence: 99%

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Hostachy

Policar

Delsuc

2017

Coordination Chemistry Reviews

112

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“…Kothari et al (62) synthesized three VIP analogs functionalized at the N terminus with histidine [VP05 (28 residue), VD4 (20 residue), VD5 (19 residue)] by solid phase synthesis and radiolabeled the VIP analogs with 99m Tc via a novel tricarbonyl synthon. All of the radiolabeled complexes were stable at room temperature and were produced with high yields.…”

Section: M Tc-labeled Vip Analogs For Receptor Imagingmentioning

confidence: 99%

Vasoactive intestinal peptide receptor-based imaging and treatment of tumors

Tang

Xin

Xie

et al. 2014

International Journal of Oncology

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Vasoactive intestinal peptide receptors (VIPRs) are members of the G-protein-coupled receptor superfamily. These receptors are overexpressed in many common malignant tumors and play a major role in the progression and angiogenesis of a number of malignancies. Therefore, VIPRs may be a valuable target for the molecular imaging of tumors and therapeutic interventions. The specific natural ligand or its analogs can be labeled with a radionuclide and used for tumor receptor imaging, which could be used to visualize VIPR-related surface protein expression in vivo and to monitor the in vivo effects of molecular drugs on tumors. Moreover, the involvement of VIPRs in malignant transformation and angiogenesis renders them potential therapeutic targets for cancer treatment. A variety of VIP antagonists and cytotoxic VIP conjugates have been synthesized and evaluated for VIPR-targeted molecular therapy. The importance of VIPRs in tumor biology and the ability to predict responses to targeted therapy and monitor drug interventions suggest that VIP receptor-based imaging and treatment will be critical for the early diagnosis and management of cancer. Here, we review the current literature regarding VIPRs and their natural ligands and the involvement of VIPRs in tumor growth and angiogenesis, with an emphasis on the present use of VIPRs for the molecular imaging of tumors and therapies targeting VIPRs.

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“…For therapy, the radiopharmaceuticals must contain radionuclides emitting ionizing particles (Auger electrons, β − or α particles) to target and damage tumor tissues. Several radiometals have nuclear decay properties suitable for therapeutic applications, such as the β − -emitting isotopes 186 Re and 188 Re (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Organometallic Complexes for SPECT Imaging and/or Radionuclide Therapy

Morais¹,

Paulo²,

Santos³

2012

Organometallics

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This article reviews Re and Tc organometallic chemistry and radiochemistry, focusing on the most relevant aspects to design radiotools for molecular imaging and therapy. The review comprises an overview of organometallic Re and Tc complexes with relevance to the field, particularly M(I) tricarbonyl complexes stabilized by a huge variety of ligands. These include Werner type chelators, cyclopentadienyls, carboranes, and poly(mercaptoazolyl)borates, which permitted the hitherto unprecedented use of M–C and M–H bonds. The most relevant biomolecules labeled with the different organometallic cores will also be reviewed, as well as the opportunities offered by the tricarbonyl approach to design high-performance perfusion agents.

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99mTc(CO)3-VIP analogues: Preparation and evaluation as tumor imaging agent

Cited by 18 publications

References 11 publications

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Vasoactive intestinal peptide receptor-based imaging and treatment of tumors

Organometallic Complexes for SPECT Imaging and/or Radionuclide Therapy

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