99mTc- and Re-labeled 6-dialkylamino-2-naphthylethylidene derivatives as imaging probes for β-amyloid plaques

Studies on acedan-based mononuclear zinc complexes toward selective fluorescent probes for pyrophosphate

“…The reaction mixture was diluted with cold water after completion of the reaction. After usual work-up, the crude product was purified by silica gel column chromatography (CH 2 Cl 2 as eluent) to yield 8a (0.3 g, 75%); 1 13 [6-(2-Bromoethylamino)naphthalen-2-yl]ethan-1-one (8b) 23 To a stirred solution of 7b (0.5 g, 2.18 mmol) and triphenylphosphine (1.72 g, 6.55 mmol) in dry THF (50 mL) in an ice bath was added NBS (1.17 g, 6.55 mmol) in small portions over a period of 10 min. After being stirred for 2 h at 0°C, it was allowed to attain room temperature.…”

“…Compounds 7c and 8c were synthesized according to the literature procedure 23 from compounds 6 and 7c, respectively.…”

Radiopharmaceuticals in China: current status and prospects

“…Therefore, the development of novel imaging agents specifically targeting A plaques may lead to early diagnosis of AD and monitoring of the effectiveness of novel therapies for this devastating disease. [10], 99m Tc-labeled benzothiazole [11,12], phenylbenzoxazole derivatives [13], 6-dialkylamino-2-naphthylethylidene derivatives [14], dibenzylideneacetone derivatives [15], and cyclopentadienyl tricarbonyl complexes mimicking chalcone [16], 125 I-labeled anilinophthalimide [17], N-benzoylindole [18], ( )-5-styryl-2,2 -bithiophene derivatives [19], ( )-5-styryl-1 -indole and ( )-6-styrylquinoline derivatives [20] have been reported in the past decade. Among them,…”

Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain

“…31,32 The tetradentate N 2 S 2 chelators, which include bisaminoethanethiol (BAT) and monoamine-monoamidedithiol (MAMA), can easily form relatively small, stable, and neutral complexes with the [ 99m TcO] 3+ core. Based on the conjugate approach, various [ 99m TcO] 3+ complexes, such as Congo red, chrysamine G, 33,34 phenylbenzothiazole, [35][36][37] phenylbenzoxazole, 38 phenylbenzofuran, 39,40 flavone, 41 aurone, 41 chalcone, 42 curcumin, 43 naphthalene, 44 dibenzylideneacetone 45 and stilbene 46 coupled with MAMA and BAT bifunctional chelators have been reported.…”