998 Intraprostatic Dysport Is a Safe and Efficacious Treatment for Benign Prostatic Hyperplasia

The use of botulinum toxin in benign prostatic hyperplasia

“…All the studies in our review reported a fall in the IPSS score from the baseline levels, except Kuo,40 Silva et al,21, 22 Park et al,12 and Sreedar et al25 A statistically significant reduction was reported in 13 studies14, 16–20, 23, 24, 26, 36, 37, 41, 42 (54.1%) with a mean reduction of 10.8 ± 2.66 points. Maria18 reported that the reduction in the IPSS score was maintained after 12 months' follow‐up (8.9 + 3.2) P = 0.001 and McVary et al36 observed a fall of 37.4% in the IPSS scores after 12 months.…”

“…Maximum urinary flow also increased in all series, and the variation was statistically significant in 14 studies (58.3%), with a mean post‐treatment increase of 6.6 + 15.6 ml/sg 11, 14, 16–21, 23, 26, 36, 38, 41, 42. Maria et al18 reported a mean increase of 6.8 ml/sec after the first month of treatment ( P = 0.001), but for Park et al12 the increase was only significant after 3 months.…”

“…The Quality of Life score fell significantly in eight series (41.6%) in all publications, with a mean decrease of 2.1 + 0.62 points 14, 16, 18, 20, 23, 26, 37, 42…”

“…The remaining studies were comprised of ten prospective cohorts,11, 16, 19, 20–23, 25, 37, 38 together with communications to congresses (presented subsequently in the supplements to their respective journals) 17, 24, 26, 34, 39, 40–42…”

“…Considering the different subtypes of botulinum toxin A, only Nikoobakht et al20, 42 used the subtype Abobotulinumtoxin A (Dysport, Ipsen Ltd, Berkshire, UK). Other authors, such as Chuang et al,11, 16, 23, 27 Park et al,12 Maria et al,18 Brisinda et al,19 Silva et al,21, 22, 41 Kuo and Liu,14 Kuo,37, 40 Jasinski et al,34 Karsenty et al,35 Agrawal et al,38 and Guercini et al39 used Onabotulinumtoxin A (Botox, Cosmetic, Allergan, Inc., Irvine, CA).…”