99% random telegraph signal-like noise in gold nanoparticle μ-stripes

Grisolia, J.; Viallet, B.; Amiens, Catherine; Baster, S; Cordan, A. S.; Leroy, Y.; Soldano, Caterina; Brügger, J.; Ressier, Laurence

doi:10.1088/0957-4484/20/35/355303

Cited by 15 publications

(15 citation statements)

References 41 publications

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“…As a result, the conductivity of this current path decreases. Similar behavior was previously found with Si NPs in SiO 2 synthesized by ultra low energy ion implantation [5] or 14 nm Au NPs with citrate ligands assembled on top of a SiO 2 layer [8]. Figure 3b presents how the current passing through the NPs assembly in SiN x substrate is modified when varying the interelectrode distance L from 2 to 50 µm.…”

Section: Device Characterisationsupporting

confidence: 77%

Electron transport through a metallic nanoparticle assembly embedded in SiO₂ and SiN_x by low energy ion implantation

Bayle

Grisolia

Assayag

et al. 2015

Phys. Status Solidi C

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Original substrates have been developed to offer a new approach to modulate and analyse simultaneously electro‐optical and transport properties through an assembly of metallic nanoparticles (NPs). Using low energy ion implantation, silver NPs have been synthesized at the vicinity of the free surface of a SiO2 or SiNx matrix. Varying the parameters of the process allows us to modify the density of NPs and their distance to the surface. While Ag NPs surface fraction in SiO2 cannot exceed 20%, it reaches 30% in SiNx. In the latter case, NPs with mean diameter is about 2.1 nm have an interdistance compatible with tunnel effect. We then developed devices that electrically address the embedded assembly of NPs for I‐V characterization. The transport measurements on these devices show that an exploitable conduction is possible within the Ag NPs assembly in SiNx. The Arrhenius‐type temperature dependence model was successfully applied demonstrating that electron transport follows a simple thermally activated behaviour with the occurrence of a strongly localized regime. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Section: Device Characterisationsupporting

confidence: 77%

Electron transport through a metallic nanoparticle assembly embedded in SiO₂ and SiN_x by low energy ion implantation

Bayle

Grisolia

Assayag

et al. 2015

Phys. Status Solidi C

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“…Nanotechnology has attracted the attention of researchers worldwide because of the unique properties of nanomaterials. Countless applications have been studied in different fields, such as medicine [ 1 , 2 ], material science [ 3 ], microelectronics [ 4 ], energy storing [ 5 ], and biomedical devices [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Elucidating Protein Involvement in the Stabilization of the Biogenic Silver Nanoparticles

et al. 2016

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Silver nanoparticles (AgNPs) have been broadly used as antibacterial and antiviral agents. Further, interests for green AgNP synthesis have increased in recent years and several results for AgNP biological synthesis have been reported using bacteria, fungi and plant extracts. The understanding of the role and nature of fungal proteins, their interaction with AgNPs and the subsequent stabilization of nanosilver is yet to be deeply investigated. Therefore, in an attempt to better understand biogenic AgNP stabilization with the extracellular fungal proteins and to describe these supramolecular interactions between proteins and silver nanoparticles, AgNPs, produced extracellularly by Aspergillus tubingensis—isolated as an endophytic fungus from Rizophora mangle—were characterized in order to study their physical characteristics, identify the involved proteins, and shed light into the interactions among protein-NPs by several techniques. AgNPs of around 35 nm in diameter as measured by TEM and a positive zeta potential of +8.48 mV were obtained. These AgNPs exhibited a surface plasmon resonance (SPR) band at 440 nm, indicating the nanoparticles formation, and another band at 280 nm, attributed to the electronic excitations in tryptophan, tyrosine, and/or phenylalanine residues in fungal proteins. Fungal proteins were covalently bounded to the AgNPs, mainly through S–Ag bonds due to cysteine residues (HS–) and with few N–Ag bonds from H2N– groups, as verified by Raman spectroscopy. Observed supramolecular interactions also occur by electrostatic and other protein–protein interactions. Furthermore, proteins that remain free on AgNP surface may perform hydrogen bonds with other proteins or water increasing thus the capping layer around the AgNPs and consequently expanding the hydrodynamic diameter of the particles (~264 nm, measured by DLS). FTIR results enabled us to state that proteins adsorbed to the AgNPs did not suffer relevant secondary structure alteration upon their physical interaction with the AgNPs or when covalently bonded to them. Eight proteins in the AgNP dispersion were identified by mass spectrometry analyses. All these proteins are involved in metabolic pathways of the fungus and are important for carbon, phosphorous and nitrogen uptake, and for the fungal growth. Thereby, important proteins for fungi are also involved in the formation and stabilization of the biogenic AgNPs.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-016-1538-y) contains supplementary material, which is available to authorized users.

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“…The unique surface chemistry of the nanomaterials is a consequence of their nanometre sizes and different shapes. This property makes them highly valuable in different applications including medicine [31], material science [32], microelectronics [33], energy storage [34] and biomedical devices [35].…”

Section: Resultsmentioning

confidence: 99%

Papain bioinspired gold nanoparticles augmented the anticancer potency of 5-FU against lung cancer

Yan

Bai

et al. 2020

Journal of Experimental Nanoscience

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Lung cancer is one of the most widely recognised types of cancer and the acquisition of resistance towards chemotherapeutic drugs worsens the situation. Therefore, a site-directed, multi-targeting drug delivery system that is compliant with patients is the need of the hour. 5-Fluorouracil (5-FU), an anti-cancer chemotherapy drug, was delivered to the lung cancer cells using papain-inspired gold nanoparticles (PpGNPs) as the drug delivery system. Papain is anti-cancer by nature; hence, it rendered this anti-cancer property to the PpGNPs as well. This bio-conjugation of 5-FU and PpGNPs worked synergistically and more efficiently in combating lung cancer. The synthesis, stability, and the size of the PpGNPs, and their bio-conjugation with 5-FU (5F-PpGNPs), were confirmed by different physical techniques: for example, UV-Vis spectroscopy, TEM, DLS, and estimation of the zeta potential. The drugloading efficiency of 5-FU in 5F-PpGNPs was confirmed and validated by UV-Vis spectroscopy. The efficacy of 5F-PpGNPs (IC 50 11.7 mg/mL) against human lung cancer A549 cell line was found to have improved significantly over that of pure 5-FU (IC 50 25.6 mg/mL). However, the 5F-PpGNPs did not show any significant toxicity (even up to a fairly high concentration) towards normal mouse embryonic fibroblasts cell line (3T3-L1). The apoptotic effects, nuclear condensation, ROS generation, and the loss of mitochondrial membrane potential (DWm) of 5F-PpGNPs were analysed. The results clearly showed that conjugation with papain-inspired gold nanoparticles (5F-PpGNPs) significantly augmented the potency of 5-FU by acting synergistically. Thus, the enhanced anti-proliferating effect of 5F-PpGNPs over that of the pure drug would be an important step that will help to ARTICLE HISTORY

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99% random telegraph signal-like noise in gold nanoparticle μ-stripes

Cited by 15 publications

References 41 publications

Electron transport through a metallic nanoparticle assembly embedded in SiO₂ and SiN_x by low energy ion implantation

Electron transport through a metallic nanoparticle assembly embedded in SiO₂ and SiN_x by low energy ion implantation

Elucidating Protein Involvement in the Stabilization of the Biogenic Silver Nanoparticles

Papain bioinspired gold nanoparticles augmented the anticancer potency of 5-FU against lung cancer

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99% random telegraph signal-like noise in gold nanoparticle μ-stripes

Cited by 15 publications

References 41 publications

Electron transport through a metallic nanoparticle assembly embedded in SiO2 and SiNx by low energy ion implantation

Electron transport through a metallic nanoparticle assembly embedded in SiO2 and SiNx by low energy ion implantation

Elucidating Protein Involvement in the Stabilization of the Biogenic Silver Nanoparticles

Papain bioinspired gold nanoparticles augmented the anticancer potency of 5-FU against lung cancer

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Product

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Electron transport through a metallic nanoparticle assembly embedded in SiO₂ and SiN_x by low energy ion implantation

Electron transport through a metallic nanoparticle assembly embedded in SiO₂ and SiN_x by low energy ion implantation