989: Anticholinergic Drugs Can Suppress Non-Neuronal ATP Release from Human Bladder Urothelium

Yoshida, Masaki; Masunaga, Koichi; Maeda, Yoshihiro; Satoji, Yo; Matsumoto, Kenshi; Yono, Makoto; Inadome, Akito; Ueda, Shoichi

doi:10.1016/s0022-5347(18)31217-5

Cited by 1 publication

(2 citation statements)

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“…It has been shown that urothelial cells express various receptors and channels including receptors for bradykinin, neurotrophins, purines (P2X and P2Y), noradrenaline (α1 and β3), Ach (muscarinic and nicotinic), protease‐activated receptors, and several members of the TRP channel and Deg/ENaC families 30 . It has been reported that stretch‐evoked ATP release is modulated by noradrenaline via α1 receptor, 31,32 TRPV1 agonists, 23 and antimuscarinic agents via M2 and M3 33 . In terms of mechanosensitive channels, the basal ATP release from the rabbit bladder epithelium is altered by amiloride, a blocker of ENaC 22 .…”

Section: Mechanosensory Machinery In the Bladdermentioning

confidence: 99%

“…30 It has been reported that stretchevoked ATP release is modulated by noradrenaline via a1 receptor, 31,32 TRPV1 agonists, 23 and antimuscarinic agents via M2 and M3. 33 In terms of mechanosensitive channels, the basal ATP release from the rabbit bladder epithelium is altered by amiloride, a blocker of ENaC. 22 In cultured urothelial cells, amiloride and Gd 3+ , a non-specific blocker of mechanosensitive channels, suppresses ATP release by a hypotonic stimulus.…”

Section: Urothelial Cellsmentioning

confidence: 99%

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Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder

Araki

Kobayashi

et al. 2008

Int J of Urology

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Abstract:In the storage phase, mechanical stretch stimulates bladder afferents. These signals generate sensations and trigger voiding responses, however the precise mechanisms by which mechanical stimuli excite bladder afferents are yet to be explored. For mechanosensory transduction, the presence of mechanosensors is essential in the peripheral sensory systems including sensory nerve endings, urothelium and others. There is increasing evidence that mechanosensitive ion channels, such as degenerin/epithelial Na + channel (ENaC) and transient receptor potential (TRP) channel families, play key roles in the mechanosensory transduction of the urinary bladder. Pharmacological interventions targeting mechanosensitive ion channels may provide a new strategy for the treatment of bladder dysfunction.

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