Abstract:BackgroundThe safety, immunogenicity, and efficacy associated with administration of of aQIV in children 6 months through 5 years of age was investigated.1 Although enhanced immunogenicity in children was demonstrated for MF59-adjuvanted influenza vaccines after first administration, the impact of repeated vaccination on immunogenicity and safety has not been evaluated.MethodsA total of 607 subjects who participated in parent study, now aged 12 months through 6 years, were enrolled the subsequent year and rece… Show more
“…In pediatric population, recent studies showed that the high-dose IV was more immunogenic than the standard one in children with leukemia or solid tumors and in solid organ transplant patients but not in children with HIV (84), with good reported safety profile (84–86). Given the relatively small studied population, despite the evidences that immunocompromised children generate a lower immune response to standard-dose IV compared to healthy subjects (87), no definitive recommendation about the use of the high-dose IV can be drawn. Notably, no data about the use of this high dose IV are available in immunocompromised children, and younger than 2 years.…”
Section: Ongoing Discussion and Future Perspectivesmentioning
Influenza vaccine is considered the most effective way to prevent influenza. Nonetheless, every year vaccine coverage is lower than recommended in the pediatric population. Many factors are supposed to contribute to this phenomenon such as the uncertainty about the indication for vaccination, and the suboptimal vaccine-effectiveness in pediatric age, especially in the youngest children. In this review we discuss the effectiveness, indications, and limits of influenza vaccination in the pediatric population based on the most recent evidences.
“…In pediatric population, recent studies showed that the high-dose IV was more immunogenic than the standard one in children with leukemia or solid tumors and in solid organ transplant patients but not in children with HIV (84), with good reported safety profile (84–86). Given the relatively small studied population, despite the evidences that immunocompromised children generate a lower immune response to standard-dose IV compared to healthy subjects (87), no definitive recommendation about the use of the high-dose IV can be drawn. Notably, no data about the use of this high dose IV are available in immunocompromised children, and younger than 2 years.…”
Section: Ongoing Discussion and Future Perspectivesmentioning
Influenza vaccine is considered the most effective way to prevent influenza. Nonetheless, every year vaccine coverage is lower than recommended in the pediatric population. Many factors are supposed to contribute to this phenomenon such as the uncertainty about the indication for vaccination, and the suboptimal vaccine-effectiveness in pediatric age, especially in the youngest children. In this review we discuss the effectiveness, indications, and limits of influenza vaccination in the pediatric population based on the most recent evidences.
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