960 Irreversible Electroporation (Ire), a Novel Technique for Focal Ablation of Prostate Cancer (Pca): Results of a Interim Pilot Safety Study in Low Risk Patients With Pca

Brausi, Maurizio; Giliberto, Giuliano; Simonini, G.; Botticelli, Laura; Gresgorio, C. Di

doi:10.1016/s1569-9056(11)60942-1

Cited by 10 publications

(7 citation statements)

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“…In the only study with protocol biopsy, residual disease was found in 27% of patients [46]. Erectile function was preserved in 89-100% while continence was maintained in 100%.…”

Section: Outcomementioning

confidence: 90%

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Health technology assessment in evolution – focal therapy in localised prostate cancer

Valério¹,

Emberton

Barret

et al. 2014

Expert Review of Anticancer Therapy

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Focal therapy in prostate cancer aims to treat only the part of the gland harboring clinically significant disease while preserving the rest of the tissue. This approach may substantially reduce treatment-related toxicity without compromising disease control outcomes. Short- to medium-term functional and oncological results in prospective interventional studies are promising, but comparative effectiveness research against standard of care is required to incorporate focal therapy among standard options. In this review, we discuss the actual stage of assessment and results of sources of energy commonly used to deliver focal therapy. We also provide our viewpoint on how the field will evolve in the near future.

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“…In the only study with protocol biopsy, residual disease was found in 27% of patients [46]. Erectile function was preserved in 89-100% while continence was maintained in 100%.…”

Section: Outcomementioning

confidence: 90%

“…Only two case series including patients treated by focal irreversible electroporation have been reported [46,47]. In the only study with protocol biopsy, residual disease was found in 27% of patients [46].…”

Section: Outcomementioning

confidence: 99%

Health technology assessment in evolution – focal therapy in localised prostate cancer

Valério¹,

Emberton

Barret

et al. 2014

Expert Review of Anticancer Therapy

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“…The first study, published by Brausi et al 14 in 2011, revealed the provisional results related to application of IE in 11 men with mean age of 70.2 years. All men had low risk disease ---10 were staged with T1c and 1 was staged with T2a.…”

Section: Clinical Outcomesmentioning

confidence: 99%

Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future?

Fernandes¹,

Pereira²

2017

aup

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In the PSA era, the incidence of localized prostate cancer has been increasing. This reality requires new therapeutic strategies, in order to give an answer to patients, in whom active surveillance may be indicate but desire more interventionist strategy with minimal side effects and without compromising cancer control. In these cases, focal therapies that include irreversible electroporation may be effective alternative strategies. The irreversible electroporation is an emergent approach on focal treatment of localized PCa. The nonthermal mechanism that preserves the tissue architecture without damaging tissue structures, such as vessels and nerves within the target region, is the main advantage comparatively to other techniques used in focal treatment. The number of clinical studies is reduced and the results still immature.

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“…After 1 mo, histopathological reports were negative in 8 patients (73 %) showing coagulative necrosis and fibrosis. 3 patients had residual disease and 2 of them underwent second IRE ablation [45].…”

Section: Prostatementioning

confidence: 99%

Irreversible Electroporation in Interventional Oncology: Where We Stand and Where We Go

Savic¹,

Chapiro²,

Hamm³

et al. 2016

Fortschr Röntgenstr

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▶ Durch nicht-thermische Ablation können "heatsink-effect" und Koagulationsverletzungen unbeteiligter Strukturen umgangen werden. Abstract ▼Irreversible electroporation (IRE) is the latest in the series of image-guided locoregional tumor ablation therapies. IRE is performed in a nearly nonthermal fashion that circumvents the "heat sink effect" and allows for IRE application in proximity to critical structures such as bile ducts or neurovascular bundles, where other techniques are unsuitable. IRE appears generally feasible and initial reported results for tumor ablation in the liver, pancreas and prostate are promising. Additionally, IRE demonstrates a favorable safety profile. However, site-specific complications include bile leaking or vein thrombosis and may be more severe after pancreatic IRE compared to liver or prostate ablation. There is limited clinical evidence in support of the use of IRE in the kidney. In contrast, pulmonary IRE has so far failed to demonstrate efficacy due to practicability limitations. Hence, this review will provide a state-of-the-art update on available clinical evidence of IRE regarding feasibility, safety and oncologic efficacy. The future role of IRE in the minimally invasive treatment of solid tumors will be discussed.

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960 Irreversible Electroporation (Ire), a Novel Technique for Focal Ablation of Prostate Cancer (Pca): Results of a Interim Pilot Safety Study in Low Risk Patients With Pca

Cited by 10 publications

References 0 publications

Health technology assessment in evolution – focal therapy in localised prostate cancer

Health technology assessment in evolution – focal therapy in localised prostate cancer

Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future?

Irreversible Electroporation in Interventional Oncology: Where We Stand and Where We Go

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