96-P: HLA-B15 subtypes in UAE population

Santhosh, Anitha; Gumama, Olanpayongan; AbdelWareth, Laila; Alvares, Marion; Mahri, Ayeda K. Al; Subahi, Elrabab; Mustafa, Manal

doi:10.1016/j.humimm.2007.08.119

Cited by 1 publication

(2 citation statements)

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“…The highest frequency of HLA‐B*15 alleles in Caucasoid, Koreans, and Japanese was B*1501 (6–8), whereas in Ni‐Vanuatu, the highest frequency was B*1506 . Although B*1503 was found in Arabs in Bubi, United Arab Emirates, Arabian Gulf Peninsula and in the African American population (10), it was not found in Burmese and other southeast Asian populations.…”

Section: Percentage Of Hla‐b*15 Subtypes Among Different B*15‐positivmentioning

confidence: 76%

“…The application of molecular typing methods has largely contributed to a more complete and accurate typing of all World Health Organization (WHO) serological specificities. In previous reports, alleles in the HLA‐B*15 group have been discovered in different ethnic groups throughout the world (5–10) with different frequencies by using several methods such as polymerase chain reaction (PCR) with sequence‐specific oligonucleotide probes (11), single‐stranded conformation polymorphism (12), sequence‐specific primer (SSP) (13) and sequence‐based typing (SBT) (14). In the clinical application, genotyping for HLA‐B*15 alleles is important in matching for solid organ and hematopoietic stem cell transplantations and genetic associations between HLA alleles and disease studies.…”

Section: Percentage Of Hla‐b*15 Subtypes Among Different B*15‐positivmentioning

confidence: 99%

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*HLA‐B**15 subtypes in Burmese population by sequence‐based typing

et al. 2009

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Human leukocyte antigen (HLA)-B*15 encompasses an increasing number of subtypes of more than 150. Frequency studies and a strong genetic association between HLA subtypes and susceptibility to drug hypersensitivity have been reported in different ethnic populations. To identify HLA-B*15 subtypes in Burmese using sequence-based typing (SBT) method, we selected 65 HLA-B*15-positive samples from 170 unrelated healthy Burmese who were genotyped HLA-B* by polymerase chain reaction with the sequence-specific primer method. The frequency of HLA-B*15 in Burmese was found to be 38.2%. By the SBT method, results showed 10 alleles of HLA-B*15 subtypes. Four common alleles, B*1502 (45.2%), B*1532 (16.4%), B*1525 (12.3%), and B*1501 (8.2%), were found in 82.1% of HLA-B*15-positive Burmese. Whereas the B*1501 was the highest in the Caucasians, Koreans, and Japanese, the highest frequency of HLA-B*15 alleles in Burmese was B*1502 (45.2%) that is similar to the frequency found in northeastern Thais and Vietnamese. This study is the first report of HLA-B*15 subtypes in Burmese. These results will provide the basic data in the further study in transplantations, genetic association with diseases, and drug hypersensitivity.

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Section: Percentage Of Hla‐b*15 Subtypes Among Different B*15‐positivmentioning

confidence: 76%