95g Tc and 96g Tc as alternatives to medical radioisotope 99m Tc

Hayakawa, Takehito; Hatsukawa, Y.; Tanimori, T.

doi:10.1016/j.heliyon.2017.e00497

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…Although the application of 99m Tc in Auger electron therapy has been proposed, other isotopes with more favourable nuclear properties are preferred [ 72 ], thus its use as a radiotherapeutic is hardly considered. Likewise, other Tc isotopes 94m Tc [ 73 ], 95g Tc and 96g Tc [ 74 ] have been identified for diagnostic uses in the PET modality, offering the possibility for acquisition of better resolution data or variation in tracer experiment durations.…”

Section: Discussionmentioning

confidence: 99%

Fusion-Based Neutron Generator Production of Tc-99m and Tc-101: A Prospective Avenue to Technetium Theranostics

Mausolf¹,

Johnstone²,

Mayordomo

et al. 2021

Pharmaceuticals

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Presented are the results of 99mTc and 101Tc production via neutron irradiation of natural isotopic molybdenum (Mo) with epithermal/resonance neutrons. Neutrons were produced using a deuterium-deuterium (D-D) neutron generator with an output of 2 × 1010 n/s. The separation of Tc from an irradiated source of bulk, low-specific activity (LSA) Mo on activated carbon (AC) was demonstrated. The yields of 99mTc and 101Tc, together with their potential use in medical single-photon emission computed tomography (SPECT) procedures, have been evaluated from the perspective of commercial production, with a patient dose consisting of 740 MBq (20 mCi) of 99mTc. The number of neutron generators to meet the annual 40,000,000 world-wide procedures is estimated for each imaging modality: 99mTc versus 101Tc, D-D versus deuterium-tritium (D-T) neutron generator system outputs, and whether or not natural molybdenum or enriched targets are used for production. The financial implications for neutron generator production of these isotopes is also presented. The use of 101Tc as a diagnostic, therapeutic, and/or theranostic isotope for use in medical applications is proposed and compared to known commercial nuclear diagnostic and therapeutic isotopes.

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Section: Discussionmentioning

confidence: 99%

Fusion-Based Neutron Generator Production of Tc-99m and Tc-101: A Prospective Avenue to Technetium Theranostics

Mausolf¹,

Johnstone²,

Mayordomo

et al. 2021

Pharmaceuticals

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“…In addition, for high energy gamma rays, the effect of Doppler broadening can be significantly reduced compared with the cases of low energy gamma rays (Zoglauer and Kanbach 2003). Other candidate radionuclides emitting high energy gamma rays suitable for Compton imaging would be 95 Tc (gamma ray of 766 keV and half-life of 20 h) and 96 Tc (gamma rays of 778, 812, and 850 keV and half-life of 4.3 d), which can substitute a standard SPECT nuclide, 99m Tc (Hayakawa et al 2018).…”

Section: Discussionmentioning

confidence: 99%

3D Compton image reconstruction method for whole gamma imaging

Tashima¹,

Yoshida²,

Wakizaka³

et al. 2020

Phys. Med. Biol.

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Compton imaging or Compton camera imaging has been studied well, but its advantages in nuclear medicine and molecular imaging have not been demonstrated yet. Therefore, the aim of this work was to compare Compton imaging with positron emission tomography (PET) by using the same imaging platform of whole gamma imaging (WGI). WGI is a concept that combines PET with Compton imaging by inserting a scatterer ring into a PET ring. This concept utilizes diverse types of gamma rays for 3D tomographic imaging. In this paper, we remodeled our previous WGI prototype for small animal imaging, and we developed an image reconstruction method based on a list-mode ordered subset expectation maximization algorithm incorporating detector response function modeling, random correction and normalization (sensitivity correction) for either PET and Compton imaging. To the best of our knowledge, this is the world’s first realization of a full-ring Compton imaging system. We selected 89Zr as an imaging target because a 89Zr nuclide emits a 909 keV single-gamma ray as well as a positron, and we can directly compare Compton imaging of 909 keV photons with PET, a well-established modality. We measured a cylindrical phantom and a small rod phantom filled with 89Zr solutions of 10.3 MBq and 10.2 MBq activity, respectively, for 1 h each. The uniform radioactivity distribution of the cylindrical phantom was reconstructed with normalization in both PET and Compton imaging. Coefficients of variation for region-of-interest values were 4.2% for Compton imaging and 3.3% for PET; the difference might be explained by the difference in the detected count number. The small rod phantom experiment showed that the WGI Compton imaging had spatial resolution better than 3.0 mm at the peripheral region although the center region had lower resolution. PET resolved 2.2 mm rods clearly at any location. We measured a mouse for 1 h, 1 d after injection of 9.8 MBq 89Zr oxalate. The 89Zr assimilated in the mouse bony structures was clearly depicted, and Compton imaging results agreed well with PET images, especially for the region inside the scatterer ring. In conclusion, we demonstrated the performance of WGI using the developed Compton image reconstruction method. We realized Compton imaging with a quality approaching that of PET, which is supporting a future expectation that Compton imaging outperforms PET.

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“…The neutron-deficient Tc isotopes, on the other hand, are also suggested as suitable candidates for medical diagnosis. For instance, the calculated γ-ray intensities of a 95 Tc g and 96 Tc g nucleus injected into the human body are 63% and 70% respectively, relative to that of a 99 Tc m nucleus, suggesting that the two nuclei can also work as γ-ray emitters of diagnosis [2]. Other than these nuclei, the 94 Tc m , with large positron branching ratio (70%) and medium positron end-point energy (2.4 MeV), is a suitable candidate for Positron Emission Tomography, and regarded as an intriguing alternative to many already popular tracers [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…where, σ J represents the cross section as a function of the total angular momentum distribution, and σ J (1) and σ J (2) refer to the cross sections associated with the ground state and isomeric state, respectively [34]. As an example, Fig.…”

mentioning

confidence: 99%

Measurement and analysis of the isomeric cross section ratios for the Tc94 nucleus

Fang

Zhou

et al. 2020

Phys. Rev. C

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We report on an isomer yield ratio study of biologically important 94 Tc following the fusion of the 9 Be + 89 Y system, carried out using the offline γ-ray spectroscopy in continuation to the online activation method. The incident beam energies considered are above the Coulomb barrier for the present study. The PLATYPUS model in conjunction with a potential model calculation was employed to analyze the data. An agreement in the order of magnitude between the experimental data and theoretical predictions has been achieved, by applying a phenomenological approach. The approach was further tested with isomer yield ratios of 94 Tc formed through 3 He + 93 Nb reactions. Possible factors that relate to the isomer yield ratios are also presented.

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95g Tc and 96g Tc as alternatives to medical radioisotope 99m Tc

Cited by 8 publications

References 41 publications

Fusion-Based Neutron Generator Production of Tc-99m and Tc-101: A Prospective Avenue to Technetium Theranostics

Fusion-Based Neutron Generator Production of Tc-99m and Tc-101: A Prospective Avenue to Technetium Theranostics

3D Compton image reconstruction method for whole gamma imaging

Measurement and analysis of the isomeric cross section ratios for the Tc94 nucleus

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