957: Congenital malformation risk according to hemoglobin A1c values in a contemporary cohort with pregestational diabetes

Abstract

risk of long-term respiratory morbidity in offspring was based on the hospital's pediatric database and a pre-defined set of respiratory ICD-9 code list associated with hospitalizations of the offspring.A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term respiratory morbidity,and a Cox proportional hazards model was constructed to control for confounders RESULTS: During the study period 242,342 deliveries met the inclusion criteria,of them4%(n¼9714)were of mothers with drug allergy.Offspring born to mothers with drug allergy had higher rates of respiratory morbidity(Table).Likewise, the cumulative incidence of long-term respiratory morbidity was higher as compared with those without drug allergy(Kaplan-Meier log rank test P¼0.022,Figure).Using a Cox proportional hazards model,controlling for confounders such as gestational age,maternal age,hypertensive disorders,caesarian section and maternal diabetes mellitus,being born to a mother with drug allergy was found to be an independent risk factor for long-term respiratory morbidity of the offspring(adjusted HR 1.2, 95% CI 1.01-1.56; P ¼ 0.040). CONCLUSION: Being born to a mother with drug allergy is independently associated with a higher risk for long-term respiratory morbidity of the offspring. Intra-uterine immunological alterations may be part of the mechanism explaining the long-term respiratory morbidity seen in offspring of women with drug allergies.

A Prospective Study of Social Needs Associated with Mental Health among Postpartum Patients Living in Underserved Communities

“…negatively impact the success of future pregnancies (32). In addition to serving as barriers to accessing quality postpartum healthcare, lack of appropriate resources independently impacts mental health (10).…”