941 Loss of Dickkopf-3 expression impairs prostate acinar morphogenesis via aberrant TGF-β/Smad signalling activation

Kawano, Yoshiaki; Romero, Diana; Bengoa, Nora; Maltry, Nicole; Walker, Mike; Eto, Masatoshi; Waxman, Jonathan; Niehrs, Christof; Kypta, Robert M.

doi:10.1016/s1569-9056(13)61420-7

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Role Of Dkk-3 Proteins In Prostate Cancer1

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2018

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“…Romero et al examined the function of DKK-3 in prostate cancer and found that silencing of DKK-3 increases proliferation of prostate epithelial cells via increasing tumor growth factor-β (TGF-β)/Smad signaling (Romero et al, 2013). In line with this, Kawano et al also showed that loss of DKK-3 expression stimulates progression of prostate cancer via activation of TGF-β/Smad signaling pathway (Kawano et al, 2013). Furthermore, forced expression of DKK-3, using an adenovirus vector, was found to induce apoptosis in human prostate cancer cell lines without endogenous DKK-3 expression.…”

Section: Role Of Dkk-3 Proteins In Prostate Cancermentioning

confidence: 93%

Therapeutic potency of Wnt signaling antagonists in the pathogenesis of prostate cancer, current status and perspectives

Pashirzad

Shafiee

Khazaei

et al. 2018

Journal Cellular Physiology

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Prostate cancer is a major cause of cancer-related death in males. Wnt/β-catenin signaling plays a critical role in the pathogenesis of this disease by regulating angiogenesis, drug resistance, cell proliferation, and apoptosis. Suppression of Wnt canonical or noncanonical signaling pathways via Wnt biological or pharmacological antagonists is a potentially novel therapeutic approach for patients with prostate cancer. This review summarizes the role of Wnt signaling inhibitors in the pathogenesis of prostate cancer for a better understanding and hence a better management of this disease.

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Section: Role Of Dkk-3 Proteins In Prostate Cancermentioning

confidence: 93%