92 Adalimumab Is More Effective Than Azathioprine and Mesalamine At Preventing Postoperative Recurrence of Crohn's Disease - A Randomized Trial

Savarino, Edoardo; Bodini, Giorgia; Dulbecco, Pietro; Marabotto, Elisa; Assandri, Lorenzo; Bruzzone, Linda; Mazza, Fabrizio; Fazio, Valentina; Giambruno, Elisa; Gemignani, Lorenzo; Savarino, Vincenzo

doi:10.1016/s0016-5085(13)60072-4

Cited by 35 publications

(47 citation statements)

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“…A total of 32 articles were excluded based on the full text article (Supplementary Figure 1), 6 of them because there was no control arm. The 9 controlled trials that fulfilled the inclusion criteria were included in the meta-analysis [5][6][7][8]11,13,[20][21][22].…”

Section: Literature Searchmentioning

confidence: 99%

“…Among these, 7 separate studies reported the efficacy of anti-TNF␣ in preventing postoperative recurrence of CD, and 2 studies reported the efficacy of anti-TNF␣ in treating the postoperative recurrence of CD. Four trials out of nine (5)(6)(7)(8) were of high quality (Jadad score ≥ 3 points).…”

Section: Literature Searchmentioning

confidence: 99%

“…More recently, other controlled trials have investigated the efficacy of anti-TNF therapy in preventing postoperative CD recurrence [6][7][8]. Accordingly, anti-TNF therapy is increasingly used for this purpose.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevention and treatment of postoperative Crohn's disease recurrence with anti-TNF therapy: A meta-analysis of controlled trials

Carla-Moreau

Paul

Roblin

et al. 2015

Digestive and Liver Disease

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Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

See 1 more Smart Citation

Prevention and treatment of postoperative Crohn's disease recurrence with anti-TNF therapy: A meta-analysis of controlled trials

Carla-Moreau

Paul

Roblin

et al. 2015

Digestive and Liver Disease

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“…3), we concluded that ADA was quite effective for this case. In addition, Savarino et al reported that administration of ADA after intestinal resective surgery was effective in preventing the endoscopic and clinical recurrence of CD [9]. In addition, it is not uncommon for patients to have a good response to biologics after removal of CD lesions.…”

Section: Discussionmentioning

confidence: 99%

Periappendicitis during adalimumab treatment for ileocecal Crohn’s disease in a 29-year-old male

Mizuno

Nakazawa

Ogawa

et al. 2015

Clin J Gastroenterol

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A 29-year-old male was diagnosed with ileocolic Crohn's disease (CD) approximately 2 years ago. Adalimumab was prescribed as CD remission induction therapy. Three months after beginning adalimumab, watery diarrhea and lower abdominal pain developed. He was admitted under a diagnosis of CD exacerbation. Despite fasting and antibiotic treatment, symptoms of acute panperitonitis appeared. He was diagnosed as acute appendicitis and we performed emergency surgery for peritoneal drainage and ileocecal resection on the fifth hospital day. We diagnosed periappendicitis based on the operative findings. This is the first report of periappendicitis with CD during adalimumab treatment.

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“…Eine Prophylaxe mit Anti-TNF-Antikörpern ist nach bisher veröffentlichten, kleinen Studien eine effektive Strategie [7,20,29]. Eine aktuell noch laufende Studie versucht dies für eine größere Hochrisikopopulation nachzuvollziehen (NCT01190839).…”

Section: Morbus Crohnunclassified

Chronisch entzündliche Darmerkrankungen: State of the Art

Maul

Siegmund

2014

Dtsch med Wochenschr

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Chronic inflammatory bowel diseases are mainly represented by Crohn's disease and ulcerative colitis. Current epidemiological data indicate a rise in incidence over the last five decades in the Western world. Consequently resulting not only in the reconsideration of the pathogenesis of inflammatory bowel diseases but furthermore emphasizing the need for a curative approach. With this review we aim to provide a concise overview on pathogenesis, diagnostics as well as therapy with a particular focus on medical strategies after ileocecal resection in Crohn's disease. In the end the near future with regard to therapeutic strategies to be introduced into daily clinical work will be described.

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92 Adalimumab Is More Effective Than Azathioprine and Mesalamine At Preventing Postoperative Recurrence of Crohn's Disease - A Randomized Trial

Cited by 35 publications

References 0 publications

Prevention and treatment of postoperative Crohn's disease recurrence with anti-TNF therapy: A meta-analysis of controlled trials

Prevention and treatment of postoperative Crohn's disease recurrence with anti-TNF therapy: A meta-analysis of controlled trials

Periappendicitis during adalimumab treatment for ileocecal Crohn’s disease in a 29-year-old male

Chronisch entzündliche Darmerkrankungen: State of the Art

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