91 Survival and causes of death in patients with elevated liver enzymes associated with non-alcoholic fatty liver disease (NAFLD)

Ekstedt, Mattias; Franzén, LE; Mathiesen, Ulrik; Holmqvist, Marika; Bodemar, Göran; Kechagias, Stergios

doi:10.1016/s0168-8278(06)80092-9

Cited by 4 publications

(6 citation statements)

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“…6,9,22 NAFLD is an insulin-resistant state, 1,[4][5][6][7]23 and patients with NAFLD should be screened regularly for metabolic disorders. 9,12,24 Although the mean serum ALT level in the fatty liver group was significantly higher than controls at both baseline and follow-up in this study, it is of interest that mean ALT values in NAFLD patients were significantly lower at follow-up compared with the corresponding value at baseline. Moreover, no patients developed cirrhotic complications during follow-up, according to clinical features, liver function tests and ultrasonography.…”

Section: Discussionmentioning

confidence: 52%

“…Therefore, NAFLD might be not merely the hepatic manifestation of MetS, but might itself also directly promote the occurrence and development of metabolic problems 6,9,22 . NAFLD is an insulin‐resistant state, 1,4–7,23 and patients with NAFLD should be screened regularly for metabolic disorders 9,12,24 …”

Section: Discussionmentioning

confidence: 99%

“…21 In a recent study from Sweden, Ekstedt et al demonstrated that survival of NAFLD patients was lower than a matched reference population mainly because of higher mortality from cardiovascular diseases, and only a trend towards higher liver-related mortality was noted among NAFLD patients. 12 Therefore, NAFLD might be not merely the hepatic manifestation of MetS, but might itself also directly promote the occurrence and development of metabolic problems. 6,9,22 NAFLD is an insulin-resistant state, 1,[4][5][6][7]23 and patients with NAFLD should be screened regularly for metabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11] Ekstedt et al reported that survival of NAFLD patients is lower compared with a matched reference population mainly because of higher mortality from cardiovascular diseases rather than liver-related mortality. 12 Therefore, it is of interest to study the course of NAFLD with a low risk of developing clinical evidence of cirrhosis, and the incidence of developing metabolic disorders and complications. This has not been studied previously in patients with NAFLD diagnosed ultrasonographically.…”

Section: Introductionmentioning

confidence: 99%

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Effects of nonalcoholic fatty liver disease on the development of metabolic disorders

Fan

Cai

et al. 2006

J of Gastro and Hepatol

162

116

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Background and Aim: Nonalcoholic fatty liver disease (NAFLD) is considered to be the liver component of metabolic syndrome. However, the impact of NAFLD on metabolic syndrome is unclear. The aim of this study was to explore the influence of NAFLD on the development of metabolic disorders. Methods: Patients with NAFLD and an age, sex, and occupation-matched control group were recruited from employees of Bao-Steel Group (Shanghai, China) who had received medical check-ups biennially between 1995 and 2002. Anthropometric and laboratory data, and incidence of metabolic disorders were assessed at baseline and at follow-up of at least 4 years. SPSS 11.5 was used for statistical analysis. Results: The study consisted of 358 patients (326 men and 32 women) and 788 matched controls (711 men and 77 women) with a similar mean age of 39.0 years and median follow-up of 6 years. At the end of follow-up, incidence of obesity (47.6% vs 19.5%), hypertension (69.6% vs 16.3%), hypertriglyceridemia (39.1% vs 16.3%), hypercholesterolemia (24.5% vs 17.3%), impaired fasting glucose (IFG) (25.1% vs 11.6%), diabetes mellitus (20.3% vs 5.2%) and multiple metabolic disorders (MMD) (56.3% vs 16.3%) were significantly higher in the fatty liver group than the control group. Interestingly, the mean alanine aminotransferase (ALT) level in patients with fatty liver significantly decreased at follow-up compared with baseline (28.56 Ϯ 18.86 vs 31.51 Ϯ 18.34 U/L, P < 0.05). To separate the effects of obesity from fatty liver, the subjects were re-classified according to the presence of obesity and fatty liver at baseline. The incidence of hypertension (61.1% vs 41.3%), hypertriglyceridemia (38.1% vs 15.0%), hypercholesterolemia (29.9% vs 16.6%), IFG (21.3% vs 10.0%) and diabetes (11.1% vs 4.3%) were significantly higher in the fatty liver group without obesity (n = 84) than in the group with without fatty liver or obesity (n = 614). In addition, the incidence of hypertension (72.9% vs 57.4%), hypertriglyceridemia (39.4% vs 22.7%) and diabetes (23.2% vs 8.4%) was higher in the group with fatty liver and obesity (n = 274) than in the group with obesity alone (n = 174). Conclusions:The presence of NAFLD might predict the development of metabolic disorders due to insulin resistance, rather than obesity itself. ALT levels decreased over time in patients with fatty liver.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of nonalcoholic fatty liver disease on the development of metabolic disorders

Fan

Cai

et al. 2006

J of Gastro and Hepatol

162

116

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“…[133][134][135][136][137] Also, in some studies the non-alcoholic fatty liver is related to cardiovascular diseases. [138][139][140][141][142][143][144] It is important to know the risk factors which result in non-alcoholic fatty liver because prevention of these risk factors can reduce the risk of non-alcoholic fatty liver. The relationship between nutrition to non-alcoholic fatty liver in human and animal has been confirmed.…”

Section: Resultsmentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease and Nutrition: A Literature Review

Hajinasrollah¹,

Foroughi²,

Jafari³

2016

Adv Food Technol Nutr Sci Open J

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What are the risk factors and settings for non‐alcoholic fatty liver disease in Asia–Pacific?

Fan

Saibara

Chitturi

et al. 2007

J of Gastro and Hepatol

236

314

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The risk factors and settings for non-alcoholic fatty liver disease (NAFLD) in Asians are reviewed comprehensively. Based particularly on large community-based studies using ultrasonography, case-control series and prospective longitudinal studies, the prevalence of NAFLD in Asia is between 12% and 24%, depending on age, gender, locality and ethnicity. Further, the prevalence in China and Japan has nearly doubled in the last 10-15 years. A detailed analysis of these data shows that NAFLD risk factors for Asians resemble those in the West for age at presentation, prevalence of type 2 diabetes mellitus (T2DM) and hyperlipidemia. The apparent differences in prevalence of central obesity and overall obesity are related to criteria used to define waist circumference and body mass index (BMI), respectively. The strongest associations are with components of the metabolic syndrome, particularly the combined presence of central obesity and obesity. Nonalcoholic fatty liver disease appears to be associated with long-standing insulin resistance and likely represents the hepatic manifestation of metabolic syndrome. Not surprisingly therefore, Asians with NAFLD are at high risk of developing diabetes and cardiovascular disease. Conversely, metabolic syndrome may precede the diagnosis of NAFLD. The increasing prevalence of obesity, coupled with T2DM, dyslipidemia, hypertension and ultimately metabolic syndrome puts more than half the world's population at risk of developing NAFLD/non-alcoholic steatohepatitis/cirrhosis in the coming decades. Public health initiatives are clearly imperative to halt or reverse the global 'diabesity' pandemic, the underlying basis of NAFLD and metabolic syndrome. In addition, a perspective of NAFLD beyond its hepatic consequences is now warranted; this needs to be considered in relation to management guidelines for affected individuals.

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91 Survival and causes of death in patients with elevated liver enzymes associated with non-alcoholic fatty liver disease (NAFLD)

Cited by 4 publications

References 0 publications

Effects of nonalcoholic fatty liver disease on the development of metabolic disorders

Effects of nonalcoholic fatty liver disease on the development of metabolic disorders

Non-Alcoholic Fatty Liver Disease and Nutrition: A Literature Review

What are the risk factors and settings for non‐alcoholic fatty liver disease in Asia–Pacific?

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