91-OR: CTRP3, a Novel Adipokine with Anti-inflammatory and Cardioprotective Properties, in Patients with Cardiovascular Diseases and Type 2 Diabetes Mellitus

Kratochvílová, Helena; Kasperová, Barbora Judita; Lacinová, Z; Lankova, Ivana; Trnovská, Jaroslava; Netuka, Ivan; Ivák, Peter; Mahrík, Jakub; Hlavacek, Daniel; Mráz, Miloš; Haluzı́k, Martin

doi:10.2337/db20-91-or

Cited by 3 publications

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“…There is also some evidence pointing out that FABP4 serum levels are significantly elevated during the early hours after onset of AMI and are robustly increased in out-of-hospital cardiac arrest survivors, probably due to rapid lipolytic release of FABP4 from epicardial fat owing to adrenergic overdrive which is characteristic of acute CVD [14]. Significantly lower plasma CTRP3 concentrations were observed in patients with coronary artery disease (CAD) and type II DM in comparison with nonCAD controls [15].…”

Section: матеріал та методи дослідження проведено з 1 вересня 2018 ро...mentioning

confidence: 99%

Relationship Between Parameters of Adipokine and Lipid Profiles in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus

Koteliukh¹

2022

psych-health

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Abstract. Introduction. Nowadays, it becomes topical to search for methods of diagnosis and treatment for polymorbid patients. The importance of the study on pathophysiological mechanisms of acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (DM) has been shown. The aim of the study: to examine the relationship between adipokine and lipid profiles in AMI patients with the presence or absence of type 2 DM. Material and methods. The study was conducted over a period from September 1, 2018 to December 31, 2020. A total of 134 patients with ST-segment elevation AMI in the presence or absence of type 2 DM aged 58.97 ± 7.92 years hospitalized in the intensive care unit of Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” and Kharkiv Railway Clinical Hospital No. 1 of the branch “Center of Healthcare” were enrolled in the study. Group 1 included 74 patients with AMI and type 2 DM aged 59.42 ± 7.66 years. Group 2 (comparison group) comprised 60 patients with AMI without type 2 DM aged 58.42 ± 8.25 years. The control group consisted of 20 otherwise healthy individuals. Serum concentrations of fatty acid-binding protein 4 (FABP4) and C1q/TNF-related protein 3 (CTRP3) of patients were measured by enzyme-linked immunosorbent assay. Serum total cholesterol (TC) and high-density lipoprotein (HDL) cholesterol were analyzed by peroxidase enzymatic method. Triglyceride (TG) levels were measured by enzymatic colorimetric method. The atherogenic index was calculated by the A.M. Klimov formula. The levels of very low-density lipoprotein (VLDL) cholesterol and low-density lipoprotein (LDL) cholesterol were estimated by the Friedewald formula. Results and discussion. The patients in Group 1 were found to have higher levels of serum TG in comparison with Group 2 patients (р<0.05). In groups 1 and 2, there was an upward tendency in the levels of TC and LDL (р ˃0.05), as well as a significant 4.04 and 2.92 times increase in VLDL, respectively, as compared to the control group (p<0.05). The serum levels of FABP4 were significantly increased, while CTRP3 levels were decreased in AMI patients compared to those in otherwise healthy individuals (р<0.05). In AMI patients with type 2 DM (group 1), an inverse correlation was found between FABP4 and VLDL (r = 0.502, p<0.05), TG (r = 0.596, p<0.001); between CTRP3 and TC (r = -0.507, p<0.05), LDL (r = -0.512, p<0.05). In patients with AMI (group 2), an inverse correlation was revealed between FABP4 and VLDL (r = 0.453, p = 0.006), TG (r = 0.439, p = 0.009); between CTRP3 and TC (r = -0.413, p = 0.001), LDL (r = -0.429, p = 0.01). Conclusions. The characteristics of changes in the FABP4 and CTRP3 serum levels are evidence of an adipokine metabolism imbalance in AMI with the presence or absence of type 2 DM, indicating a metabolic shift in this patient category. The relationship between lipid profile markers and FABP4 and CTRP3 may indicate the influence of the latter on lipid metabolism.

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Section: матеріал та методи дослідження проведено з 1 вересня 2018 ро...mentioning

confidence: 99%

Relationship Between Parameters of Adipokine and Lipid Profiles in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus

Koteliukh¹

2022

psych-health

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“…Serum CTRP3 levels are associated with CVD and type 2 DM 14 . Kratochvilova et al 15 report that CTRP3 may be a diagnostic and prognostic marker of CVD in patients with long-lasting type 2 DM. However, the issues of late complications after MI considering adropin and CTRP3 in type 2 DM patients need to be addressed.…”

Section: List Of Abbreviationsmentioning

confidence: 99%

"A Model for Predicting Late Complications of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus"

Koteliukh¹

2022

Arch Balk Med Union

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Modèle de prédiction des complications tardives de l'infarctus du myocarde chez les patients avec diabète de type 2Introduction. Les complications tardives de l'infarctus du myocarde (IDM) constituent l'une des principales causes de ré hospitalisation et de mortalité parmi les patients avec diabète de type 2. L'objectif de l'étude était de prévoir le développement des complications tardives de l'IDM chez les patients avec diabète de type 2 ce qui a permis d'améliorer les méthodes diagnostiques chez cette cohorte de patients. Matériel et méthodes. Le total de 109 patients qui ont développé un diabète de type 2 après avoir subi un IDM, a été divisé en deux groupes : un groupe expérimental (n = 74) et un groupe témoin (n = 35). La détermination de l'adropine et C1q/Protéine 3 induite par le facteur de nécrose tumorale (CTRP3) a été réalisée au moyen de la méthode de dosage immuno-enzymatique. Le modèle de prédiction des complications tardives de l'IDM a été évalué en utilisant la régression logistique binaire.

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“…The effect of CTRP3 on cardiac fibrosis was examined, and significantly decreased CTRP3 expression after AMI was determined. 15 . However, the relationship between CTRP3 and the occurrence of early complications in type 2 DM patients after AMI remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Predictive model for early complications of acute myocardial infarction in patients with type 2 diabetes mellitus

Koteliukh

Dorosh²

2022

Biomed. Res. Ther.

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Introduction:Early complications of acute myocardial infarction (AMI) are one of the leading causes of death among patients with type 2 diabetes mellitus (DM). Clinical and laboratory characteristics and noninvasive methods need to be integrated to better identify early complications of AMI and further develop a treatment strategy. The aim of the study was to predict the development of early complications after AMI in type 2 DM patients, which could improve the quality of preventive and curative measures for this group of patients. Methods: In total, 109 patients with ST-elevation myocardial infarction (STEMI) and type 2 DM were included in the study: 75 men and 34 women. The training set (n = 74) was selected to study variables associated with the probability of early complications after AMI in type 2 DM patients. The model reproducibility was then checked on the validation set (n = 35). All patients underwent percutaneous coronary intervention (PCI). The training set identified 26 patients with early complications and 48 patients without early complications of AMI. The validation set identified 18 patients with early complications and 17 patients without early complications of AMI. The model for predicting early AMI complications was calculated using binary logistic regression. Results: The developed mathematical model for predicting early complications of AMI was as follows: Р = [1+ exp(-(0.030 × C1q tumor necrosis factor-related protein 3 (CTRP 3) (ng/ml) + 1.414 × respiratory rate (RR) (breaths per minute) + 0.322 × body mass index (BMI) (kg/m2) + 0.091× heart rate (HR) (beats per minute) -50.800))] −1 . The model yielded the highest results under the receiver operating characteristic curve for predicting early complications of AMI among the diabetic patients in both the training and validation groups (0.962 and 0.928, respectively). Conclusions : This study has shown that integral measurements of circulating CTRP 3 content, RR, BMI, and HR upon admission of STEMI patients with type 2 DM after PCI could predict early complications of AMI. These findings suggest a new approach to stratify the risk of early AMI complications in type 2 DM patients after successful coronary revascularization.

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91-OR: CTRP3, a Novel Adipokine with Anti-inflammatory and Cardioprotective Properties, in Patients with Cardiovascular Diseases and Type 2 Diabetes Mellitus

Cited by 3 publications

References 0 publications

Relationship Between Parameters of Adipokine and Lipid Profiles in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus

Relationship Between Parameters of Adipokine and Lipid Profiles in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus

"A Model for Predicting Late Complications of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus"

Predictive model for early complications of acute myocardial infarction in patients with type 2 diabetes mellitus

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