(909/Paper 324)

Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy

“…51 Of the five CPSP predictors identified by Althaus and colleagues, our findings are consistent with two: preoperative pain in the operating field and other preoperative pain. The relevance of preoperative pain in another area of the body is possibly attributable to poor functioning of endogenous pain inhibition mechanisms, as has been demonstrated in patients who develop CPSP after thoracotomy 14 and in several chronic pain settings. 52 Factors related to surgery and anesthetic technique were not predictors of CPSP (Supplemental Digital Content 3, table 4).…”

“…[3][4][5][6] The main predictors described to date are female sex, 7 age, 8 psychosocial factors, 9,10 a history of pain in the region of surgery or other sites, 5,8,11 type of procedure, 3,4,12 nerve injury, 13 and postoperative pain intensity. 14 Additionally, genetic polymorphisms have been linked to varying sensitivity to pain, 15,16 susceptibility to certain painful conditions, 17 and response to analgesics, [18][19][20] leading some to suggest that such factors might explain why some patients develop chronic pain and others do not. 3,4,21 Studies with sufficient power to confirm the relevance of single nucleotide polymorphisms (SNPs) have yet to be published, although they are potentially of considerable interest.…”

Prevalence and factors associated with persistent pain following body contouring surgery

“…Différents tests ont été développés au fil des années dans le but de diagnostiquer la part neuropathique des douleurs comme le questionnaire Douleur Neuropathique 4 (DN4) (13) ou le score S-LANSS (Leeds Assessment of Neuropathic Symptoms and Signs pain scale) (14) ; et pour identifier les patients à risque (15).…”