903 Fractal Analysis Differentiation of Nuclear and Vascular Patterns in Hepatocellular Carcinomas and Hepatic Metastasis

Streba, Costin Teodor; Pirici, Daniel; Mogoantă, Laurențiu; Comănescu, Maria; Rogoveanu, Ion; Săndulescu, Larisa; Bold, Adriana

doi:10.1016/s0168-8278(10)60904-x

Cited by 15 publications

(30 citation statements)

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“…Fractal studies on images of malignant tissues have revealed an increase in fractal dimension in malignant v.s normal tissue and an increase in fractal dimension/complexity with tumor grade in many different forms of cancer including brain [50,51], breast [52,53], cervical [52,54] and hepatocellular carcinomas [55]. These studies demonstrate the clinical potential of fractal analysis in the diagnosis and grading of malignant tumors.…”

Section: Cancermentioning

confidence: 76%

“…Moreover, fractal studies have demonstrated a decrease in fractal dimension of the CNS with illness (i.e., Alzheimer's [42], epilepsy [23,24], MS [45], stroke [49]) which correlates with metabolic studies demonstrating a decline in glucose metabolism with illness [83,85,88,[90][91][92][93][94][95][96][97][101][102][103]. Conversely, there are diseases which demonstrate an increase in fractal dimension including cancer [50][51][52][53][54][55] and grey matter structural changes in MS [46]. Of significance, these diseases which demonstrate an increase in fractal dimension also demonstrate an increase in glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, fractal studies on the microvasculature of grade II and grade III gliomas have demonstrated an increase in fractal dimension with tumor grade [50,51]. Furthermore, studies of hepatocelluar carcinomas have shown an increase in the fractal dimension of vasculature structures in malignant tissue compared to normal tissue, where the vessels of primary tumors showed greater fractal dimension when compared with hepatic metastases [55]. Conversely, fractal studies have also demonstrated that the microvasculature in normal pituitary tissue is more complex than in benign pituitary adenomas [56] and correlates with earlier findings demonstrating reduced microvascular complexity in malignant PRL producing carcinomas vs. benign pituitary adenomas [57].…”

Section: Cancermentioning

confidence: 99%

“…Advantages of such tracers include lower background activity in normal brain tissue and improved detection of low-grade tumors [111,[118][119][120]. In relation to fractal dimension, the hypermetabolism of cancer cells corresponds to the increase in fractal dimension in malignant tissue and with tumor grade in many different forms of cancer including brain [50,51], breast [52,53], cervical [52,54] and hepatocellular carcinomas [55]; and also corresponds to the increase in fractal dimension of tumor vasculature as seen in gliomas [50,51] and hepatocelluar carcinomas [55].…”

Section: Cancermentioning

confidence: 99%

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Fractal Structure and Entropy Production within the Central Nervous System

Seely

Newman

Herry

2014

Entropy

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Abstract:Our goal is to explore the relationship between two traditionally unrelated concepts, fractal structure and entropy production, evaluating both within the central nervous system (CNS). Fractals are temporal or spatial structures with self-similarity across scales of measurement; whereas entropy production represents the necessary exportation of entropy to our environment that comes with metabolism and life. Fractals may be measured by their fractal dimension; and human entropy production may be estimated by oxygen and glucose metabolism. In this paper, we observe fractal structures ubiquitously present in the CNS, and explore a hypothetical and unexplored link between fractal structure and entropy production, as measured by oxygen and glucose metabolism. Rapid increase in both fractal structures and metabolism occur with childhood and adolescent growth, followed by slow decrease during aging. Concomitant increases and decreases in fractal structure and metabolism occur with cancer vs. Alzheimer's and multiple sclerosis, respectively. In addition to fractals being related to entropy production, we hypothesize that the emergence of fractal structures spontaneously occurs because a fractal is more efficient at dissipating energy gradients, thus maximizing entropy production. Experimental evaluation and further understanding of limitations and necessary conditions are indicated to address broad scientific and clinical implications of this work.

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Section: Cancermentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

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Fractal Structure and Entropy Production within the Central Nervous System

Seely

Newman

Herry

2014

Entropy

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“…The technological future developments include virtual microscopy. Fractal analysis [92] and quantitative IHC can be applied [93].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Primary and Metastatic Tumours of the Liver: Expanding Scope of Morphological and Immunohistochemical Details in the Biopsy

Štrumfa¹,

Vilmanis²,

Vanags³

et al. 2012

Liver Biopsy - Indications, Procedures, Results

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Cancer and viruses: A double‐edged sword

Butt¹,

Miggin

2012

Proteomics

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Oncovirus, synonymously called a 'tumour virus', is a virus that can cause cancer. An oncolytic virus preferentially infects the host's cancer cells and lyses them, causing tumour destruction, and is thus referred to as a 'cancer killing virus'. With an estimated 11% of cancer-associated deaths caused by oncoviruses and the possibility that many cancers may be treated by using oncolytic viruses, the role of viruses in cancer may be viewed as a double-edged sword. A total of seven human cancer viruses have been identified as oncoviruses, having been associated with various cancers. Conversely, a large number of oncolytic viruses have shown great potential towards the treatment of certain types of cancer. Proteomics has now been applied towards understanding the complex interplay that exists between oncoviruses and the immune responses that serve to prevent oncoviral diseases. This review attempts to summarise the neoplastic potential of human tumour associated viruses and associated vaccine successes. The potential use of oncolytic viruses for the therapeutic intervention of cancer will also be discussed. Finally, this review will discuss the enormous potential of proteomics technology in the field of oncovirology.

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903 Fractal Analysis Differentiation of Nuclear and Vascular Patterns in Hepatocellular Carcinomas and Hepatic Metastasis

Cited by 15 publications

References 0 publications

Fractal Structure and Entropy Production within the Central Nervous System

Fractal Structure and Entropy Production within the Central Nervous System

Primary and Metastatic Tumours of the Liver: Expanding Scope of Morphological and Immunohistochemical Details in the Biopsy

Cancer and viruses: A double‐edged sword

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