90 Years of progesterone: Ninety years of progesterone: the ‘other’ ovarian hormone

Ali, Simak; Balachandran, K.; O’Malley, Bert W.

doi:10.1530/jme-20-0145

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Progesterone and other progestational agents have several clinical applications, and extensive research has been conducted to evaluate the physiological effects and also the side effects of exogenous progesterone administration [67]. Progesterone is the only native ligand [68], while progestogens comprise all substances that activate PR and result in progesterone-like effects, and progestins are synthetic PR agonists [69].…”

Section: Clinical Implications Of Progesteronementioning

confidence: 99%

Key to Life: Physiological Role and Clinical Implications of Progesterone

Nagy

Szekeres-Barthó

Kovaćs

et al. 2021

IJMS

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The most recent studies of progesterone research provide remarkable insights into the physiological role and clinical importance of this hormone. Although the name progesterone itself means “promoting gestation”, this steroid hormone is far more than a gestational agent. Progesterone is recognized as a key physiological component of not only the menstrual cycle and pregnancy but also as an essential steroidogenic precursor of other gonadal and non-gonadal hormones such as aldosterone, cortisol, estradiol, and testosterone. Based on current findings, progesterone and novel progesterone-based drugs have many important functions, including contraception, treatment of dysfunctional uterine bleeding, immune response, and prevention of cancer. Considering the above, reproduction and life are not possible without progesterone; thus, a better understanding of this essential molecule could enable safe and effective use of this hormone in many clinical conditions.

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Section: Clinical Implications Of Progesteronementioning

confidence: 99%

Key to Life: Physiological Role and Clinical Implications of Progesterone

Nagy

Szekeres-Barthó

Kovaćs

et al. 2021

IJMS

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“…As one of the most important sex steroids and key cyclical reproductive hormones with major impacts on the female organs of vertebrate species, progesterone (PRG) is mainly produced by the corpus luteum (CL) of the ovaries. Besides its reproductive significance, PRG can also be generated from the adrenal cortex, Leydig cells of the male testes, adipose cells and neuronal and glial cells [ 1 , 2 , 3 , 4 , 5 , 6 ], reaffirming its wide range of physiological effects, especially in the metabolic systems, central nervous systems and reproductive systems in both genders [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. PRG was first purified almost a century ago as an ovarian steroid with hormonal function for pregnancy [ 8 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Besides its reproductive significance, PRG can also be generated from the adrenal cortex, Leydig cells of the male testes, adipose cells and neuronal and glial cells [ 1 , 2 , 3 , 4 , 5 , 6 ], reaffirming its wide range of physiological effects, especially in the metabolic systems, central nervous systems and reproductive systems in both genders [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. PRG was first purified almost a century ago as an ovarian steroid with hormonal function for pregnancy [ 8 , 17 ]. Since its identification, the main function of PRG was quickly realized as pro-gestational proliferation during pregnancy [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…20 years after the discovery of nPRs, PRG was also found to evoke rapid membrane and cytoplasm changes, defined as rapid, non-classic or non-genomic actions [ 26 , 27 , 28 ], opening a new venue for our understanding of the physiological functions of PRG-mediated actions. Currently, most results are generated from classic PRG-nPRs signaling cascades in the reproductive system due to the nPRs’ much earlier discovery [ 7 , 8 , 9 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Membrane Progesterone Receptors (mPRs/PAQRs) Are Going beyond Its Initial Definitions

et al. 2023

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Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but can also be generated from other sources such as the adrenal cortex, Leydig cells of the testes and neuronal and glial cells. PRG has wide-ranging physiological effects, including impacts on metabolic systems, central nervous systems and reproductive systems in both genders. It was first purified as an ovarian steroid with hormonal function for pregnancy, and is known to play a role in pro-gestational proliferation during pregnancy. The main function of PRG is exerted through its binding to progesterone receptors (nPRs, mPRs/PAQRs) to evoke cellular responses through genomic or non-genomic signaling cascades. Most of the existing research on PRG focuses on classic PRG-nPR-paired actions such as nuclear transcriptional factors, but new evidence suggests that PRG also exerts a wide range of PRG actions through non-classic membrane PRG receptors, which can be divided into two sub-classes: mPRs/PAQRs and PGRMCs. The review will concentrate on recently found non-classical membrane progesterone receptors (mainly mPRs/PAQRs) and speculate their connections, utilizing the present comprehension of progesterone receptors.

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