9-Oxo-neoprocurcumenol fromCurcuma aromatica(Zingiberaceae) as an Attachment Inhibitor against the Blue Mussel,Mytilus edulis galloprovincialis

Etoh, Hideo; Kondoh, Takeyoshi; Yoshioka, Nohoko; Sugiyama, Kimio; Ishikawa, Hajime; Tanaka, Hitoshi

doi:10.1271/bbb.67.911

Cited by 19 publications

(8 citation statements)

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“…(Zingiberaceae), also known as “white turmeric” is a perennial herb, largely found in tropical countries including Malaysia, Indonesia, India and Thailand [ 1 ]. In Malaysia, it is known as “temu putih” and is widely consumed as spice, flavoring agent for native dishes and an additive in food preparations for women in confinement after child birth [ 2 , 3 ]. It is extensively used in folk medicine for the treatment of menstrual disorders, dyspepsia, vomiting, and blood stagnation [ 1 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorometric and Molecular Docking Studies on the Binding of Curcumenol and Curcumenone to Human Serum Albumin

Hamdi

Feroz

Shilpi

et al. 2015

IJMS

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Curcumenol and curcumenone are two major constituents of the plants of medicinally important genus of Curcuma, and often govern the pharmacological effect of these plant extracts. These two compounds, isolated from C. zedoaria rhizomes were studied for their binding to human serum albumin (HSA) using the fluorescence quench titration method. Molecular docking was also performed to get a more detailed insight into their interaction with HSA at the binding site. Additions of these sesquiterpenes to HSA produced significant fluorescence quenching and blue shifts in the emission spectra of HSA. Analysis of the fluorescence data pointed toward moderate binding affinity between the ligands and HSA, with curcumenone showing a relatively higher binding constant (2.46 × 105 M−1) in comparison to curcumenol (1.97 × 104 M−1). Cluster analyses revealed that site I is the preferred binding site for both molecules with a minimum binding energy of −6.77 kcal·mol−1. However, binding of these two molecules to site II cannot be ruled out as the binding energies were found to be −5.72 and −5.74 kcal·mol−1 for curcumenol and curcumenone, respectively. The interactions of both ligands with HSA involved hydrophobic interactions as well as hydrogen bonding.

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Section: Introductionmentioning

confidence: 99%

Spectrofluorometric and Molecular Docking Studies on the Binding of Curcumenol and Curcumenone to Human Serum Albumin

Hamdi

Feroz

Shilpi

et al. 2015

IJMS

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“…Also known as temu putih in Malaysia and Indonesia, C. zedoaria is widely consumed as spice, a flavouring agent in native dishes and is frequently used in food preparations for women during post-partum confinement [ 2 , 3 ]. It has long been used as a folk medicine in different Asian countries for the treatment of menstrual disorders, dyspepsia, vomiting, cancer, stomachic, blood stagnation, hepato-protection and for promoting menstruation [ 1 , 4 , 5 ]. The rhizomes of C. zedoaria is considered as a rich source of terpenoids [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Quantum Chemical and Statistical Study of Cytotoxic Activity of Compounds Isolated from Curcuma zedoaria

Hamdi

Anouar

Shilpi

et al. 2015

IJMS

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A series of 21 compounds isolated from Curcuma zedoaria was subjected to cytotoxicity test against MCF7; Ca Ski; PC3 and HT-29 cancer cell lines; and a normal HUVEC cell line. To rationalize the structure–activity relationships of the isolated compounds; a set of electronic; steric and hydrophobic descriptors were calculated using density functional theory (DFT) method. Statistical analyses were carried out using simple and multiple linear regressions (SLR; MLR); principal component analysis (PCA); and hierarchical cluster analysis (HCA). SLR analyses showed that the cytotoxicity of the isolated compounds against a given cell line depend on certain descriptors; and the corresponding correlation coefficients (R2) vary from 0%–55%. MLR results revealed that the best models can be achieved with a limited number of specific descriptors applicable for compounds having a similar basic skeleton. Based on PCA; HCA and MLR analyses; active compounds were classified into subgroups; which was in agreement with the cell based cytotoxicity assay.

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“…[2] It is used traditionally for the treatment of menstrual disorders, dyspepsia, vomiting [3] and for cancer. [4] Rural people use the rhizome for its rubefacient, carminative, expectorant, demulcent, diuretic and stimulant properties while the root is used in the treatment of flatulence, dyspepsia, cold, cough and fever. [1] Zedoaria is a herbaceous and rhizomatous perennial plant composed of an upright pseudostem, a corm and underground cylindrical branches or rhizomes and fleshy roots.…”

Section: Introductionmentioning

confidence: 99%

Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

Lobo¹,

Prabhu²,

Shirwaikar³

2009

j pharm pharmacol

129

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9-Oxo-neoprocurcumenol fromCurcuma aromatica(Zingiberaceae) as an Attachment Inhibitor against the Blue Mussel,Mytilus edulis galloprovincialis

Cited by 19 publications

References 1 publication

Spectrofluorometric and Molecular Docking Studies on the Binding of Curcumenol and Curcumenone to Human Serum Albumin

Spectrofluorometric and Molecular Docking Studies on the Binding of Curcumenol and Curcumenone to Human Serum Albumin

A Quantum Chemical and Statistical Study of Cytotoxic Activity of Compounds Isolated from Curcuma zedoaria

<I>Curcuma zedoaria</I> Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

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