9-Acridone-4-carboxylic acid as an efficient Cr(III) fluorescent sensor: Trace level detection, estimation and speciation studies

Karak, Debasis; Banerjee, Arnab; Sahana, Animesh; Guha, Subarna; Lohar, Sisir; Adhikari, Susanta; Das, Debasis

doi:10.1016/j.jhazmat.2011.01.110

Cited by 62 publications

(19 citation statements)

References 29 publications

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“…Cr 6+ could also be determined by reducing Cr 6+ to Cr 3+ with Na 2 SO 3 . In another approach, Das et al 25 reported a fluorescent ligand Cr-2 for Cr 3+ based on the affinity of hard binding sites (N, O) of the acridone derivative towards Cr 3+ . Upon addition of Cr 3+ ions, quenching of the fluorescence intensity at 498.4 nm occurred in DMF-H 2 O (9/1, v/v).…”

Section: Cr(iii) Sensorsmentioning

confidence: 99%

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

et al. 2015

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Transition metals (d-blocks) are recognized as playing critical roles in biology, and they most often act as cofactors in diverse enzymes; however, improper regulation of transition metal stores is also connected to serious disorders. Therefore, the monitoring and imaging of transition metals are significant for biological research as well as clinical diagnosis. In this article, efforts have been made to review the chemical sensors that have been developed for the detection of the first-row d-block metals (except Cu and Zn): Cr, Mn, Fe, Co, and Ni. We focus on the development of fluorescent sensors (fall into three classes: "turn-off", "turn-on", and ratiometric), colorimetric sensors, and responsive MRI contrast agents for these transition metals (242 references). Future work will be likely to fill in the blanks: (1) sensors for Sc, Ti, and V; (2) MRI sensors for Cr, Mn, Co, Ni; (3) ratiometric fluorescent sensors for Cr(6+), Mn(2+), and Ni(2+), explore new ways of sensing Fe(3+) or Cr(3+) without the proton interference, as well as extend applications of MRI sensors to living systems.

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Section: Cr(iii) Sensorsmentioning

confidence: 99%

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

et al. 2015

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“…[26] Therefore, an accurate and reliable method for the determination of chromium ions is important. The detection of chromium ions in water samples has been performed by a variety of techniques, including electrothermal atomic absorption spectrometry, [27,28] atomic absorption spectrometry, [29] fluorescence spectroscopy, [30][31][32] potentiometric membrane sensing, [33] and electrolysis. [34] Among the many detection methods, colorimetric detection based on gold nanoparticles is particularly attractive for point-of-use applications owing to its low cost, speed, and especially ease of readout (even with the naked eye).…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of 2,6‐Pyridinedicarboxylic Acid Protected Gold Nanoparticles with Sensitive Chromium‐Ion Sensing and Efficient Catalysis

Yang

Ren

et al. 2015

Eur J Inorg Chem

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The detection of Cr3+ and Cr6+ ions is very important as they are dangerous pollutants and carcinogens. Herein, we describe the preparation of 2,6‐pyridinedicarboxylic acid functionalized gold nanoparticles (PDCA–AuNPs) and their application as colorimetric sensors for the detection of Cr3+ and Cr6+ ions in water samples. The PDCA–AuNPs could be induced to aggregate quickly in the presence of Cr3+ ions, and the aggregation can be observed through the colorimetric response and special localized surface plasmon resonance (LSPR) of the gold nanoparticles. A linear response to the concentration of Cr3+ ions was observed from 10 nM to 1 μM. The detection limit is as low as 2 nM, which is below the maximum recommended contamination level of the World Health Organization for the chromium content (0.962 μM) in drinking water. The highly specific interactions of Cr3+ ions with PDCA–AuNPs provided excellent selectivity towards the detection of Cr3+ ions over other metal ions (Pb2+, Mg2+, Zn2+, Ni2+, Cu2+, Co2+, Ca2+, Mn2+, Fe2+, Cd2+, Ba2+, Cr6+, Ag+, Fe3+, Al3+, and Hg2+). Additionally, Cr6+ ions can be determined through the detection of Cr3+ ions after reduction by ascorbic acid. This method can offer the additional advantage of the efficient detection of Cr3+ and Cr6+ ions over other ions in environmental lake water. Additionally, the PDCA–AuNPs can be used as an efficient catalyst for the reduction of 4‐nitrophenol (4‐NP) and K3[Fe(CN)6].

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“…Some of these novel acridone derivatives act as topoisomerase inhibitors , DNA intercalators or selective telomeric G‐quadruplex DNA ligands . Antitumor efficacy of acridone derivatives have been examined using several techniques, including mass spectrometry by probing protein–target interactions , fluorescence analysis for DNA binding activity and other traditional molecular biological technologies for protein and gene expressions .…”

Section: Introductionmentioning

confidence: 99%

Changes in cellular glycosylation of leukemia cells upon treatment with acridone derivatives yield insight into drug action

et al. 2016

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A new acridone derivative 2-aminoacetamido-10-(3, 5-dimethoxy)-benzyl-9(10H)-acridone hydrochloride (8a) has been shown to have potent antitumor activity. In order to understand the underlying action mechanism of 8a, three compounds of the same class with structures optimized step-by-step, 9(10H)-acridone (A), 10-(3,5-dimethoxy) benzyl-9(10H)-acridone (I) and 8a, were exposed to CCRF-CEM leukemia cell to determine the N-glycosylation changes using the microfluidic HPLC-chip-TOF MS platform. N-Glycans from whole cell lysates (WCL) and cell membranes (CM) were analyzed using isomer-sensitive chip-based porous graphitized carbon nano-LC/MS. A total of 223 N-glycan compositions and 398 N-glycan compounds were identified. Comparison of the two analyses showed that more apparent changes were observed in the CM compared with WCL, suggesting that CM may be a more sensitive indicator of changes in glycosylation. Upon 8a exposure to CCRF-CEM cells, a significant decrease in high-mannose-type glycans was observed. Different expressions of oligosaccharyltransferase subunits appear to play a key functional role in regulating the hypoglycosylation and contribute to the action mechanism of 8a. Taken together our findings suggest that glycosylation is strongly affected by therapeutic potency and can be used as possible biomarkers for monitoring toxicity and antitumor activity of 8a.

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9-Acridone-4-carboxylic acid as an efficient Cr(III) fluorescent sensor: Trace level detection, estimation and speciation studies

Cited by 62 publications

References 29 publications

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

Facile Preparation of 2,6‐Pyridinedicarboxylic Acid Protected Gold Nanoparticles with Sensitive Chromium‐Ion Sensing and Efficient Catalysis

Changes in cellular glycosylation of leukemia cells upon treatment with acridone derivatives yield insight into drug action

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9-Acridone-4-carboxylic acid as an efficient Cr(III) fluorescent sensor: Trace level detection, estimation and speciation studies

Cited by 62 publications

References 29 publications

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

Facile Preparation of 2,6‐Pyridinedicarb­oxylic Acid Protected Gold Nanoparticles with Sensitive Chromium‐Ion Sensing and Efficient Catalysis

Changes in cellular glycosylation of leukemia cells upon treatment with acridone derivatives yield insight into drug action

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Facile Preparation of 2,6‐Pyridinedicarboxylic Acid Protected Gold Nanoparticles with Sensitive Chromium‐Ion Sensing and Efficient Catalysis