9;22 Translocation and bcr rearrangements in chronic myelocytic leukemia patients among atomic bomb survivors.

Tanaka, Kimio; Takechi, Miho; J, Hong; Shigeta, Chiharu; Oguma, Nobuo; Kamada, Nanao; Takimoto, Yukie; Kuramoto, Atsushi; Dohy, Hiroo; Kyo, Taiichi

doi:10.1269/jrr.30.352

Cited by 18 publications

(5 citation statements)

References 8 publications

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“…A more relevant issue in this case is whether the CML was induced by the conditioning regimen used for auto‐transplantation. Based on studies of the survivors of the atomic bombs dropped on Hiroshima and Nagasaki in World War II [9], it has long been known DNA‐damaging agents such as ionizing radiation increase the incidence of CML, and in vitro work has shown that the appearance of BCR‐ABL fusion genes can be induced in cells by ionizing radiation [10]. It thus seemed possible that conditioning with cyclophosphamide might have caused DNA breaks that led to the appearance of the BCR‐ABL ‐positive clone in our patient.…”

Section: Commentarymentioning

confidence: 99%

An asymptomatic 61‐year‐old man with BCR‐ABL‐positive bone marrow following autologous transplantation for multiple myeloma

et al. 2010

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A 60-year-old male was referred with a recent diagnosis of multiple myeloma. He presented at an outside institution with severe low back pain due to pathologic compression fractures of the thoracic spine treated with T12 vertebroplasty and T11 kyphoplasty. Workup at our institution demonstrated an IgA kappa monoclonal protein (M-spike) of 1.83 g/dl. Bone marrow examination showed that 25% of the marrow cellularity consisted of plasma cells. Cytogenetic analysis was not performed. Blood studies showed: total calcium, 10.7 mg/dl; hemoglobin, 12.4 g/dl; hematocrit, 33.7%; albumin, 3.6 g/dl; and b2 microglobulin, 5.3 lg/ml. His 24-hour urine electrophoresis showed a total protein of 23.2 mg in 24 hours. The kappa free light chain was 69.7 mg/L, the lambda free light chain was 2.25 mg/L, and the kappa/lambda ratio was 31 (normal 0.26-1.65). Radiologic studies revealed diffuse osteopenia and lytic lesions in the humeri and the pelvic bones.

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Section: Commentarymentioning

confidence: 99%

An asymptomatic 61‐year‐old man with BCR‐ABL‐positive bone marrow following autologous transplantation for multiple myeloma

et al. 2010

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“…Tanaka et al [ 92 ] studied chromosomal abnormalities and bcr -locus rearrangements in seven CML atomic bomb survivors and compared with fourteen CML unirradiated patients. They found that all CML patients contained BCR-ABL1 p210 fusion protein.…”

Section: Pfgs Induced By Irmentioning

confidence: 99%

Preleukemic Fusion Genes Induced via Ionizing Radiation

Košík

Skorvaga

Belyaev

2023

IJMS

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Although the prevalence of leukemia is increasing, the agents responsible for this increase are not definitely known. While ionizing radiation (IR) was classified as a group one carcinogen by the IARC, the IR-induced cancers, including leukemia, are indistinguishable from those that are caused by other factors, so the risk estimation relies on epidemiological data. Several epidemiological studies on atomic bomb survivors and persons undergoing IR exposure during medical investigations or radiotherapy showed an association between radiation and leukemia. IR is also known to induce chromosomal translocations. Specific chromosomal translocations resulting in preleukemic fusion genes (PFGs) are generally accepted to be the first hit in the onset of many leukemias. Several studies indicated that incidence of PFGs in healthy newborns is up to 100-times higher than childhood leukemia with the same chromosomal aberrations. Because of this fact, it has been suggested that PFGs are not able to induce leukemia alone, but secondary mutations are necessary. PFGs also have to occur in specific cell populations of hematopoetic stem cells with higher leukemogenic potential. In this review, we describe the connection between IR, PFGs, and cancer, focusing on recurrent PFGs where an association with IR has been established.

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“…One of the intriguing questions is, what predisposes to the translocation in the first place? Although ionising radiation has been implicated (Tanaka et al , 1989) it is more likely a result of the error‐prone non‐homologous end‐joining mechanism (Wiemels & Greaves, 1999; Elliott & Jasin, 2002). The BCR and ABL genes are in close physical proximity in the nucleus (Neves et al , 1999) and it is possible that breaks in the DNA are illegitimately repaired and result in a translocation that gives the cell a survival advantage.…”

Section: The Biology Of Ph+ Allmentioning

confidence: 99%

Philadelphia positive acute lymphoblastic leukaemia of childhood

Jones

Saha

2005

Br J Haematol

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Summary On current chemotherapeutic regimens, children with Philadelphia positive acute lymphoblastic leukaemia show a heterogeneous response to treatment. A few respond quickly to treatment and achieve long‐term remission. Some fail to achieve remission after induction and the majority respond slowly to treatment. Relapse on treatment is common and remission is sustained in a proportion of cases only after allogeneic stem cell transplantation (allo‐SCT). The use of imatinib along with conventional cytoreductive therapy, prior to allo‐SCT appears to be the most promising strategy. The future lies in the molecular evaluation of response to treatment and combination targeted chemotherapy.

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9;22 Translocation and bcr rearrangements in chronic myelocytic leukemia patients among atomic bomb survivors.

Cited by 18 publications

References 8 publications

An asymptomatic 61‐year‐old man with BCR‐ABL‐positive bone marrow following autologous transplantation for multiple myeloma

An asymptomatic 61‐year‐old man with BCR‐ABL‐positive bone marrow following autologous transplantation for multiple myeloma

Preleukemic Fusion Genes Induced via Ionizing Radiation

Philadelphia positive acute lymphoblastic leukaemia of childhood

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