9,11-Seco steroids. Attempt to separate biological activities via ring cleavage

Chinn, Leland J.; Dygos, John H.; Mares, Stanley E.; Aspinall, Richard L.; Ranney, R. E.

doi:10.1021/jm00249a021

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Estrogen Replacement Therapy For Osteoporosis2

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2005

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“…Improvements in tissue selectivity have been observed with a family of D-ring halogenated estrones which have demonstrated potent lipid lowering yet diminished uterine hypertrophy relative to estrone . Other attempts to attenuate the estrogenic activity of steroids on the uterus by opening of the steroid nucleus, such as 9,11-seco steroids, have met with only limited success. , …”

Section: Estrogen Replacement Therapy For Osteoporosismentioning

confidence: 99%

“…105 Other attempts to attenuate the estrogenic activity of steroids on the uterus by opening of the steroid nucleus, such as 9,11-seco steroids, have met with only limited success. 106,107 A synthetic steroid with weak estrogenic, progestational, and androgenic properties that has been examined clinically is Tibolone (OD-14). 108 Tibolone has been used to treat climacteric syndome without inducing endometrial stimulation.…”

Section: Estrogen Replacement Therapy For Osteoporosismentioning

confidence: 99%

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