Abstract:Aim: The objectives of the present research were ssto observe the effect of N-methyl-D-aspartate (NMDA) receptor antagonist on Parkinson model(s) in rats and to compare the efficacy of NMDA receptor antagonist with standard antiparkinson drug. Materials and Methods: Albino rats were divided into five experimental groups of six each. 24 animals except normal and acute dose of haloperidol (1 mg/kg) were administered intraperitoneally for induction of catalepsy. Six animals received saline 0.9% NaCl and served as… Show more
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