8Gy single-dose radiotherapy is effective in metastatic spinal cord compression: Results of a phase III randomized multicentre Italian trial

Maranzano, Ernesto; Trippa, Fabio; Casale, M.; Costantini, Sara; Lupattelli, Marco; Bellavita, Rita; Marafioti, L.; Pergolizzi, Stefano; Santacaterina, Anna; Mignogna, Marcello; Silvano, Giovanni; Fusco, Vincenzo

doi:10.1016/j.radonc.2009.05.012

Cited by 175 publications

(99 citation statements)

References 41 publications

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“…However, Rades et al showed that, compared with short-course radiotherapy, longcourse radiotherapy resulted in significantly better 1-year local control (81% vs. 61%, p = 0.005) 12 . The incidence of reported treatment-related adverse events was similar for all regimens, with dysphagia, esophagitis, diarrhea, and skin reaction being frequently reported 12,27,29,30 .…”

Section: Radiotherapymentioning

confidence: 85%

“…Radiotherapy-related toxicities such as vomiting, esophagitis, dysphagia, and skin reactions have been reported 23,24 . Five studies of various radiation regimens showed no difference in terms of back pain relief, of posttreatment maintenance, improvement, or regain of ambulation, and of toxicities 12,[27][28][29][30] . However, Rades et al 12 demonstrated that long-course radiotherapy was associated with improved local control of spinal metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of Metastatic Spinal Cord Compression: cepo Review and Clinical Recommendations

L’Espérance¹,

Vincent²,

Gaudreault

et al. 2012

Current Oncology

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the Comité de l'évolution des pratiques en oncologie• long-course radiotherapy be administered to patients with inoperable spinal cord compression and good life expectancy.• decompressive surgery followed by long-course radiotherapy be offered to appropriate symptomatic mscc patients (including spinal instability, displacement of vertebral fragment); and • patients considered for surgery have a life expectancy of at least 3-6 months.

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Section: Radiotherapymentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Treatment of Metastatic Spinal Cord Compression: cepo Review and Clinical Recommendations

L’Espérance¹,

Vincent²,

Gaudreault

et al. 2012

Current Oncology

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show abstract

“…Spinal stability is decreased during bone damage in tumor lesions, which have manifested as local fractures, vertebral compression fractures and scoliosis, accompanied by varying degrees of bone-derived pain and compression symptoms of nerve root or spinal cord (12,13). Therefore, reconstructing the stability of the vertebral body or improving the mechanical index of the affected vertebra to effectively relieve bone-derived pain is the goal for therapy (14,15).…”

Section: Traditional Methods For Treating Cancer Metastasis Of Posterimentioning

confidence: 99%

Advances in the clinical research of the minimally invasive treatment for the posterior edge of vertebral-body defects by spinal metastases

et al. 2015

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Abstract.Spinal metastasis is one of the commonly observed complications in the advanced stages of cancer patients, and is a serious threat to human life and health. Malignant tumor invasion usually leads to defects in the posterior margins of the vertebral body, which caused significant cancer pains to patients and increased the risk of surgery. Currently, minimally invasive treatments of vertebral defects caused by spinal metastases include percutaneous vertebroplasty (PVP) combined with radiofrequency ablation and PVP combined with 125 I seed implantation. These minimally invasive techniques have particular superiority to control pain in patients with spinal metastases, improve nerve function, reduce the incidence of fractures and surgical risk, and improve the quality of life. The present study reviewed the progress in clinical research on vertebral defects caused by spinal metastases, and the mechanisms and minimally invasive treatment.

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“…6 In another randomised study of 327 patients by the same authors, the median duration of improvement in motor function was 4.5 months after 1x8Gy compared with five months after 2x8Gy in eight days (p=0.4). 8 However, these authors did not differentiate between recurrences within (in-field recurrence) or outside (out-field recurrence) the previously irradiated area of the spinal cord. Therefore, while these studies are helpful in terms of functional outcomes, they are not particularly helpful if one aims to define the optimal fractionation regime in terms of local control.…”

Section: Impact Of the Fractionation Regimenmentioning

confidence: 99%

“…[3][4][5][6][7][8] Thus, short-course RT may be considered for the treatment of MSCC. This particularly applies to patients with a poor expected survival of only a few months.…”

mentioning

confidence: 99%

Local Control of Metastatic Spinal Cord Compression Following Radiotherapy

Rades¹,

Schild²

2010

European Oncology &Amp; Haematology

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Up to 10% of all cancer patients will develop metastatic spinal cord compression (MSCC) during the course of their disease. Impact of the Fractionation RegimenMany different fractionation regimens are used worldwide for the RT of MSCC. These include single-fraction regimens such as 1x8Gy, multifraction short-course regimens such as 4x4Gy over four days, 5x4Gy over one week or 5x5Gy over one week, and multifraction longcourse regimens such as 10x3Gy over two weeks, 15x2.5Gy over cord. Long-course RT (30-40Gy in two to four weeks) results in significantly better local control than short-course RT and should therefore be administered to patients with a more favourable survival prognosis. Survival can be estimated with a newly developed scoring system. If re-irradiation is required, a second course of RT can be safely administered in most cases after primary short-course RT. After primary long-course RT, re-irradiation should optimally be performed with high-precision techniques in order to reduce the risk of radiation-related myelopathy.

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8Gy single-dose radiotherapy is effective in metastatic spinal cord compression: Results of a phase III randomized multicentre Italian trial

Cited by 175 publications

References 41 publications

Treatment of Metastatic Spinal Cord Compression: cepo Review and Clinical Recommendations

Treatment of Metastatic Spinal Cord Compression: cepo Review and Clinical Recommendations

Advances in the clinical research of the minimally invasive treatment for the posterior edge of vertebral-body defects by spinal metastases

Local Control of Metastatic Spinal Cord Compression Following Radiotherapy

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