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Katae, Hiromi

doi:10.3147/jsfp.17.77

Cited by 11 publications

(1 citation statement)

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“…14) Antibiotics have been used in aquaculture as an effective method to control lactococcosis, the most commonly used drugs being oxytetracycline, erythromycin and amoxicillin. 20,21) However, the safety of using antibiotics has been questioned. The development of drug-resistant bacteria and the accumulation of antibiotics in fish and the environment have been reported to be associated with the use of antibiotics in aquaculture.…”

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confidence: 99%

Protective Effect of Clove Oil-Supplemented Fish Diets on ExperimentalLactococcus garvieaeInfection in Tilapia

Rattanachaikunsopon

Phumkhachorn

2009

Bioscience, Biotechnology, and Biochemistry

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The essential oils extracted from the four herbs, cinnamon (Cinnamomum verum), clove (Syzygium aromaticum), ginger (Zingiber officinale) and holy basil (Ocimum sanctum), were investigated for their antimicrobial activity and mode of action against Lactococcus garvieae, a fish pathogenic bacteria causing lactococcosis. Of all the tested oils, clove oil had the strongest inhibitory effect and exhibited a bactericidal mode of action against the pathogenic bacterium. When an intraperitoneal infection of tilapia (Oreochromis niloticus) with L. garvieae was performed, the median lethal dose (LD(50)) was determined to be 1.78x10(2) CFU/fish. For an in vivo trial, no mortality was apparent in fish fed on the fish diets supplemented with 3% (w/w) of clove oil and with 0.5% (w/w) of oxytetracycline 5 d prior to the infection with L. garvieae. These results indicate that clove oil had a protective effect on experimental L. garvieae infection in tilapia and the potential to replace antibiotics for controlling the disease.

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confidence: 99%