89Yttrium nuclear magnetic resonance studies

Abstract

With a Fourier-transform spectrometer, especially developed for nuclei with weak NMR signals, the lines of 89y have been investigated in aqueous solutions of Y(NO3)3, YC13, and Y(C104) 3. The concentration dependence of the chemical shifts of the 89y resonance frequencies in these solutions were measured. Using this dependence, the Larmor frequency of the 89 y3 + ion solely surrounded by water was determined by extrapolation. The Larmor frequency of 89y was referred to those of 2H, 39K, and 73Ge with high accuracy. The magnetic moment of the agy3+ ion purely surrounded by H20 molecules is #(sgy3+)= -0.136 852 3 (4) #N. The concentration dependence of Y(NO 3) 3 solutions in D 20 yields the solvent isotope effect 3(89Y 3+ in D20)-cS(89Y 3+ in H20)=-(4.3+0.5)ppm. The S9y relaxation times T 1 and T 2 of a 3 molal aqueous Y(NO3) 3 solution were determined in the pH range-0.5... +1.25. T~=190...90s is nearly constant in this range, whereas the transverse relaxation rate T2-1 increases strongly with increasing pH; this effect seems to be due to the chemical exchange of the hydrated y3+ ion between a monomer and a polymer site.

Hyperpolarized 89Y Offers the Potential of Direct Imaging of Metal Ions in Biological Systems by Magnetic Resonance

“…8 With the advent of FT spectrometers, a few more reports appeared demonstrating that 89 Y salts have unusually long T 1 values and are concentration dependent. 9 More interestingly, Levy et al 10 were first to show that complexation of 89 Y 3+ with crown ethers of various ring size resulted in the lengthening of T 1 about 4-fold over that measured for salts dissolved in DMSO. In 1990, Holz and Horrocks used 89 Y 3+ as a Ca 2+ surrogate and reported that the chemical shift of various chelated forms of Y 3+ varies widely, ranging from 36.6 ppm when bound at the EF site of parvalbumin to 129.6 ppm in Y(EDTA) -.…”

“…Only one 89 Y NMR study was reported prior to the 1970s . With the advent of FT spectrometers, a few more reports appeared demonstrating that 89 Y salts have unusually long T 1 values and are concentration dependent . More interestingly, Levy et al were first to show that complexation of 89 Y 3+ with crown ethers of various ring size resulted in the lengthening of T 1 about 4-fold over that measured for salts dissolved in DMSO.…”