893 The Immunoregulatory Properties of Helicobacter pylori DNA On Conventional Dendritic Cells

Owyang, Stephanie Y.; Paul, Jose; Zhang, Min; Kao, John Y.

doi:10.1016/s0016-5085(09)60622-3

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rad et al (2006) have demonstrated higher expression levels of Foxhead box protein 3 (FoxP3) in H. pylori-infected individuals. This hypothesis is also supported by the recent work of Owyang et al (2009), who demonstrated that H. pylori DNA has immunoregulatory properties, which may assist the organism with evading the immune mechanisms of the host. Certainly, an imbalance between effector and regulatory T cells appears to be important in IBD immunology.…”

Section: Helicobacter Pylori and Ibdmentioning

confidence: 62%

“…It may therefore be that the relative immunosuppression initiated by H. pylori infection protects against other inflammatory gastrointestinal conditions such as IBD. This hypothesis is also supported by the recent work of Owyang et al (2009), who demonstrated that H. pylori DNA has immunoregulatory properties, which may assist the organism with evading the immune mechanisms of the host. We would add two further hypotheses that may explain the apparent protective effect of H. pylori.…”

Section: Helicobacter Pylori and Ibdmentioning

confidence: 62%

See 1 more Smart Citation

Could Helicobacter organisms cause inflammatory bowel disease?

Hansen¹,

Thomson²,

Fox³

et al. 2010

FEMS Immunology &Amp; Medical Microbiology

View full text Add to dashboard Cite

The discovery of Helicobacter pylori sparked a revolution in the understanding and management of peptic ulcer disease and gastric cancer. Other Helicobacter species are recognized as important pathogenic agents in colitic diseases of rodents and primates, in particular Helicobacter bilis, Helicobacter fennelliae, Helicobacter hepaticus and Helicobacter trogontum. Helicobacter bilis and H. hepaticus are now routinely used to initiate rodent models of inflammatory bowel disease (IBD), particularly in immunocompromised hosts. Molecular evidence exists linking various non-pylori Helicobacter spp. with human IBD; however, attempts to culture organisms in this disease cohort have proved unsuccessful to date. Attributing causation has therefore proved elusive. Seven enterohepatic, non-pylori Helicobacter organisms have been successfully cultured from humans, namely Helicobacter canadensis, Helicobacter canis, Helicobacter cinaedi, H. fennelliae, Helicobacter pullorum, Helicobacter winghamensis and Helicobacter sp. flexispira taxon 8 (now classified as H. bilis). Of these, H. cinaedi and H. fennelliae are the closest to fulfilling Koch's postulates as causative agents in homosexual proctitis. The possibility that novel Helicobacter organisms have a role in the initiation of human IBD warrants further consideration and targeted investigations.

show abstract

Section: Helicobacter Pylori and Ibdmentioning

confidence: 62%

Section: Helicobacter Pylori and Ibdmentioning

confidence: 62%