876 Manipulation of stem cell divisional behavior: Selectively promoting asymmetric and symmetric keratinocyte divisions in vitro

Abstract

Dermal Wnt/b-catenin is active prior to and during hair follicle development and is essential for hair follicle initiation. However, it remains unknown how dermal Wnt signaling controls hair follicle specification. In this study, we have begun to address the role of dermal Wnt/bcatenin in hair follicle initiation by ablating b-catenin expression in dermal cells at specific time points during skin development using an inducible genetic approach. We show that loss