87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

Manchanda, Yusman; Jones, Ben; Carrat, Gaëlle; Ramchunder, Zenouska; Marchetti, Piero; Leclerc, Isabelle; Thennati, Rajamannar; Burade, Vinod; Tomás, Alejandra; Rutter, Guy A.

doi:10.2337/db21-87-lb

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tirzepatide is a dual GIP and GLP-1 receptor agonist, a novel combination drug class that has been referred to as "twincretin." 1,[13][14][15][16] GLP-1 and GIP are the main hormones involved in the incretin effect, which occurs following food consumption. Both hormones stimulate the production of insulin in response to a meal, but GIP has the additional functions of increasing glucagon secretion in a hypoglycemic state and affecting lipid homeostasis.…”

Section: Clinical Pharmacologymentioning

confidence: 99%

Tirzepatide

2022

View full text Add to dashboard Cite

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433.

show abstract

Section: Clinical Pharmacologymentioning

confidence: 99%