866-3 Assessment of left ventricular torsional deformation by doppler tissue imaging: A validation study using tagged magnetic resonance imaging

Notomi, Yuichi; Setser, Randolph M.; Shiota, Takahiro; Martin-Miklovic, Maureen G.; Kasper, J; Popović, Zoran B.; Yamada, Hirotsugu; Deserranno, Dimitri; Greenberg, Neil L.; García, Mario J.; White, Richard D.; Thomas, James D.

doi:10.1016/s0735-1097(04)91576-8

Cited by 56 publications

(107 citation statements)

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“…The average LV rotation and rotational velocity profi le from six segments is used for the calculation of LV twist and twist velocity. LV twist and twist velocity is defi ned as apical rotation and rotational velocity relative to the base of the heart [7,14,16].…”

Section: How To Measure LV Twistmentioning

confidence: 99%

Evaluation of left ventricular function using left ventricular twist and torsion parameters

Takeuchi

Otsuji²,

Lang³

2009

Curr Cardiol Rep

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The left ventricular (LV) twist/torsion, wringing motion of the heart is a key element for regulating LV systolic and diastolic mechanics. Until recently, the evaluation of LV twist was limited to the research arena because of the requirement of invasive techniques or low availability of tagged MRI. The recent development of two-dimensional speckle tracking echocardiography enables the noninvasive measurement of LV rotation in humans. This article constitutes a practical guide for the measurement and interpretation of LV twist parameters using two-dimensional speckle tracking echocardiography and discusses its clinical usefulness for the evaluation of LV function.

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Section: How To Measure LV Twistmentioning

confidence: 99%

Evaluation of left ventricular function using left ventricular twist and torsion parameters

Takeuchi

Otsuji²,

Lang³

2009

Curr Cardiol Rep

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“…As in previous studies [2][3][4][5][6]: (1) LV torsion was defined as the net difference of LV rotation at the basal and apical planes (Fig. 2); (2) to adjust for intersubject differences in heart rate, the time sequence was normalized.…”

Section: The 2d Strain Processingmentioning

confidence: 99%

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction using 2-dimensional strain imaging

Han

Xie

et al. 2010

Front. Med. China

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The recent development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing left ventricular (LV) torsion. This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patients with anterior wall myocardial infarction (AMI). A total of 55 AMI patients were divided into two groups according to their ejection fraction (EF) values (group A: LVEF≥50%; group B: LVEF < 50%), and 35 normal people served as the control group. Using 2-dimensional strain software, global and regional LV rotation and displacement were obtained at two planes. Compared with the control group, patients of group A showed reduced peak LV twist of the anterior and anterior-septal wall (9.26AE1.89 vs 10.74AE2.67; 9.71AE1.71 vs 11.36AE2.29, both P < 0.05), but the radial displacement and global twist were maintained (P > 0.05). Differently, regional and global LV twist and radial displacement in patients of group B deceased significantly, especially in the anterior and anterior-septal wall, as compared with patients in the control or group A (both P < 0.05). Moreover, a strong correlation was noted between peak twist and radial displacement; the twist-displacement loop was markedly distorted in patients of group B. This study demonstrated that 2D strain has a potential ability for quantification of left ventricular global and segment twist and radial displacement in patients with coronary artery disease.

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“…The validation tests were based on available experimental/clinical cardiovascular data gathered from a total of 12 normal volunteers at the Cleveland Clinic Foundation as published by Notomi et al 17 The protocol was approved by the institutional review board and written, informed consent was obtained before the study from all patients. The average age and weight of the group was 36 ± 8 years and 72 ± 10 kg, respectively.…”

Section: Numerical Experiments 3: Validation Against In Vivo Clinical mentioning

confidence: 99%

“…Echocardiographic images were analyzed for standard indices of systolic and diastolic function. Additional details about experimental protocols and/ or data analysis can be found in the works of Notomi et al 17 Non-invasive and direct measurement of ventricular pressure is not possible, therefore a total of six 25-30 kg mongrel dogs were used to obtain mean values of invasive pressure measurements to supplement noninvasive data obtained in the human experimental model. Detailed information about the treatment of the animals and experimental protocols can be found in the work of Notomi et al 16 The study was approved by the Institutional Animal Research committee and is in compliance with the ''Guide for the Care and Use of Laboratory Animals published by the National Institutes of Health.''…”

Section: Numerical Experiments 3: Validation Against In Vivo Clinical mentioning

confidence: 99%

“…7, a 100% error in an index indicates that the model prediction for that index is off by 1 standard deviation. Therefore, the histogram shows that 18 (2) systemic pressure, minimum (3) and maximum (4) LV pressure, minimum (5) and maximum (6) time derivative of LV pressure, peak left atrial pressure (7), end-diastolic (8) and end-systolic (9) LV volume, stroke volume (10), ejection fraction (11), cardiac output (12), heart rate (13), ejection time (16), peak S/E/A-wave velocities (15)(16)(17), time-velocity-integral of the E-wave (18) and E/A-velocity ratio (19). flow velocities in the atria, ventricles, arteries, and valves) during one heartbeat are presented in Fig.…”

Section: Numerical Experiments 3: Validation Against In Vivo Clinical mentioning

confidence: 99%

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Incorporation of Myofilament Activation Mechanics into a Lumped Model of the Human Heart

2007

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The success and usefulness of lumped cardiovascular models are directly dependent on the physiological fidelity of their formulation. In most existing lumped formulations for the heart, the compliance of the chamber is modeled based on its electrical analog, the capacitor. This has traditionally resulted in the use of a pre-described time-varying stiffness modulus for simulating the cardiac contractions. Unfortunately, such a time-varying stiffness does not include any physiological contractile machinery and thus no dependency on fiber sarcomere length and intracellular calcium concentrations, key mechanisms responsible for proper cardiac function. In this paper a lumped cardiovascular model is presented that is based on the incorporation of detailed myofilament activation for simulating the ventricular calcium binding and cross-bridging mechanism. Upon validation against experimental data, it is shown that the new myofilament activation-based model considerably increases the physiological validity and internal consistency of the cardiovascular simulations in comparison to the traditional variable compliance-based models. It is also shown, through specific case studies, that the present model can serve as a quick response tool for testing various hypotheses concerning the impact of the calcium binding and crossbridge kinetics on the overall performance of the cardiovascular system.

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866-3 Assessment of left ventricular torsional deformation by doppler tissue imaging: A validation study using tagged magnetic resonance imaging

Cited by 56 publications

References 0 publications

Evaluation of left ventricular function using left ventricular twist and torsion parameters

Evaluation of left ventricular function using left ventricular twist and torsion parameters

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction using 2-dimensional strain imaging

Incorporation of Myofilament Activation Mechanics into a Lumped Model of the Human Heart

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