860 The tumor markers CEA, MCA AND CA-19-9 at pleural effusions and primary tumor of the lung

Kaeva, Biserka; Stefanovski, Tome; Polenaković, B; Demireva, M.; Naumovski, E; Stojkovski, S.

doi:10.1016/s0169-5002(97)80241-3

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“…In a prospective study that aimed to assess the diagnostic value of serum CEA, cytokeratin 19 fragment marker (CYFRA 21-1) and Neuron-Specific Enolase (NSE) in the differentiation of malignant from benign solitary pulmonary lesions, serum CEA recorded the highest sensitivity (27.2%) and accuracy (40.4%) when used as a tumor marker alone [25] . In another study [12] , the highest sensitivity (85.3%) was found in serum CEA. The diagnostic accuracy was 74% for serum CEA, which was higher than NSE (66%) and CA-50 antigen (62%) [4] .…”

Section: Discussionmentioning

confidence: 83%

Relationship between Nickel Exposure and the Level of Carcinoembryonic Antigen among Welders in an Automotive Plant

Juan¹

2009

American Journal of Applied Sciences

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Background: Study on the effect of nickel exposure in the occupational setting and its association to carcinoembryonic antigen (CEA) had been studied before. Questions were raised whether the result from previous study would also show the same pattern of the urinary nickel concentration in this study. Objective: A cross-sectional study was conducted to determine the association between urine nickel concentration and CEA level among welders in automotive part workers in Malaysia. Methodology: There were 56 welders and 44 administrative workers were recruited in this study. Urine and blood samples were collected at the end of shift towards the end of workweek. CEA was assayed in serum using TECO Diagnostic ELISA Kit. Urinary nickel was determined by Graphite Furnace Atomic Absorption Spectrophotometer. Results: The mean carcinoembryonic antigen concentrations of the exposed group (4.07±2.60 ng mL −1 ) was significantly higher (p<0.001) than the control group (1.99±0.97 ng mL −1 ). Twenty seven percent of the exposed group showed values above the reference range. The mean urinary nickel level was also significantly higher (p<0.001) in the exposed group (1.99±0.91 mg L −1 ) than the control group. Result showed correlation between serum carcinoembryonic antigen concentration and urinary nickel concentration (r = 0.206). Conclusion: The significant elevation of urinary nickel levels in the welders compared with controls suggests that the welders were exposed to nickel fumes during welding. It is suggested that elevation of serum carcinoembryonic antigen was due to exposure to nickel during welding processes after controlling other confounding factors.

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Section: Discussionmentioning

confidence: 83%

Relationship between Nickel Exposure and the Level of Carcinoembryonic Antigen among Welders in an Automotive Plant

Juan¹

2009

American Journal of Applied Sciences

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860 The tumor markers CEA, MCA AND CA-19-9 at pleural effusions and primary tumor of the lung

Cited by 1 publication

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Relationship between Nickel Exposure and the Level of Carcinoembryonic Antigen among Welders in an Automotive Plant

Relationship between Nickel Exposure and the Level of Carcinoembryonic Antigen among Welders in an Automotive Plant

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