859 Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?

Matsumura, Kiyoshi; Arima, Hisatomi; Tominaga, Mitsuhiro; Ohtsubo, Toshio; Sasaguri, Toshiyuki; Fujii, Koji; Fukuhara, Mikio; Uezono, Keiko; Morinaga, Yuki; Ohta, Yuko; Otonari, Takatoshi; Kawasaki, Junya; Kato, Isao; Tsuchihashi, Takuya

doi:10.1097/01.hjh.0000420908.20967.65

Cited by 1 publication

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“…Disease CVD (n = 11) [35,45,48,49,52,[58][59][60][61][62][63] HT (n = 31) [5,33,[38][39][40][41][42]46,53,55,56,[64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83]] DMII (n = 10) [31,32,36,43,44,51,54,[84][85][86]] HIV (n = 14) [30,…”

Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

“…Most of the studies (n = 62; 93%) relied only on one method; however, five studies [35,50,59,79,82] combined two different methods to assess medication adherence. The applied methods could be divided into two broad categories: subjective (e.g., patient interviews and self-reporting) and indirect (e.g., pill counts, methods using prescription fills, electronic monitoring) [75]. Some of the methods are more general and applicable to more cases, whereas some were used only in a specific study.…”

Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

“…Patient is considered adherent, if the percentage is between 80% and 110%. n = 6 [30,35,47,73,75,91] Morisky scale General Questionnaire containing eight questions; a self-assessment scale. Based on the sum of the scores.…”

Section: Study-specific/ General Short Description Assessment Of Levementioning

confidence: 99%

“…FDCT, fixed-dose combination therapy; MPT, multipill therapy; CVD, cardiovascular disease; DMII, diabetes mellitus type 2; LUTS/BHP, Lower urinary tract symptoms associated with benign prostatic hyperplasia; HIV, human immunodeficiency virus. Figure 3 shows the risk of bias summary for all seven randomized controlled trials [35,45,48,52,59,75,88]. As previously noted, blinding of participants was impossible due to the nature of the intervention, that is, different pill burden, resulting in high risk of performance bias in all studies.…”

Section: Adherence Outcomementioning

confidence: 99%

“…Thus, it was decided to be omitted from the overall risk of bias assessment. Based on the previously determined criteria, two RCTs reached standards for having an overall low risk of bias [48,52], two studies reached standards for having a medium risk of bias [35,59], and three studies were considered as having a high overall risk of bias [45,75,88].…”

Section: Adherence Outcomementioning

confidence: 99%

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Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

et al. 2020

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Many patients, especially those with a high pill burden and multiple chronic illnesses, are less adherent to medication. In medication treatments utilizing polypills, this problem might be diminished since multiple drugs are fused into one formulation and, therefore, the therapy regimen is simplified. This systematic review summarized evidence to assess the effect of polypills on medication adherence. The following databases were searched for articles published between 1 January 2000, and 14 May 2019: PubMed, Web of Science, Cochrane Library, and Scopus. Medication adherence was the only outcome assessed, regardless of the method of measuring it. Sixty-seven original peer-reviewed articles were selected. Adherence to polypill regimens was significantly higher in 56 articles (84%) compared to multiple pill regimens. This finding was also supported by the results of 13 out of 17 selected previously published systematic reviews and meta-analyses dealing with this topic. Adherence can be improved through the formulation of polypills, which is probably why the interest in researching them is growing. There are many polypills on the market, but the adherence studies so far focused mainly on a small range of medical conditions.

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Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

Section: Study-specific/ General Short Description Assessment Of Levementioning

confidence: 99%

Section: Adherence Outcomementioning

confidence: 99%

Section: Adherence Outcomementioning

confidence: 99%

See 3 more Smart Citations

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

et al. 2020

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show abstract

859 Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?

Cited by 1 publication

References 0 publications

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

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