There is an overall perception of increased interdisciplinarity in science, but this is difficult to confirm quantitatively owing to the lack of adequate methods to evaluate subjective phenomena. This is no different from the difficulties in establishing quantitative relationships in human and social sciences 1 . In this paper we quantified the interdisciplinarity 2 of scientific journals and science fields by using an entropy measurement 3, 4 based on the diversity of the subject categories of journals citing a specific journal. The methodology consisted in building citation networks using the Journal Citation Reports database, in which the nodes were journals and edges were established based on citations among journals. The overall network for the 11-year period (1999-2009) studied was small-world 5 and scale free 6 with regard to the in-strength. Upon visualizing the network topology an overall structure of the various science fields could be inferred, especially their interconnections. We confirmed quantitatively that science fields are becoming increasingly interdisciplinary, with the degree of interdisplinarity (i.e. entropy) correlating strongly with the in-strength of journals and with the impact factor. The tremendous advances in scientific methods and increase in computational power in the last few decades have allowed increasingly complex problems to be addressed and solved 7,8 . Because such types of problems are intrinsically interdisciplinary, this has reinforced the pan-multidisciplinary nature of many naturally-occurring phenomena and man-made systems. In a sense, this movement brought science closer to the paradigm adopted by Greek philosophers who treated Nature as a landscape of knowledge glued together in an indivisible discipline. Not surprisingly, in recent years new areas have been established with this interdisciplinary character, as is the case of nanoscience and nanotechnology, in addition to new disciplines arising from the merging of two or more areas, such as computational biology and biomolecular physics. The interdisciplinary global structure of knowledge has not received much attention in the literature, probably due to the difficulty in quantifying how interdisciplinary a given topic or piece of work is 1, 2, 9 . A possible approach to deal with such intricate relationships is to treat large systems as complex networks 6, 10 , which are convenient to represent complex system structures where subsystems are the vertices and their interactions are represented by edges in a graph. Though built from simple elements, these networks may present high complexity both in size and in topology 11 , thus providing an adequate framework to capture the complex behavior of systems without narrowing the study to simple, isolated systems.In this paper we used concepts from complex networks to evaluate quantitatively 2 the interdisciplinarity of science fields and journals. The citation networks were built in a different manner from the conventional one employed in the literature. Rather than taki...