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Cline, David A.; Dalby, Richard N.

doi:10.1023/a:1020338405947

Cited by 95 publications

(21 citation statements)

References 7 publications

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“…54, No. 11 18) supposed a certain minimum surface energy interaction between a drug and lactose particles is needed to pull highly cohesive micronized drug particles apart and increase FPF. This appears to conflict with the following two observations.…”

Section: Inhalation Properties Of Dpi Of Compound a And Lactose Effecmentioning

confidence: 99%

“…Recently, utilization of IGC is growing rapidly and evaluation of pharmaceutical materials such as mannitol, lactose monohydrate, trehalose and albuterol has been reported. [16][17][18][19] Though it is said more research is required for the fundamental understanding of this technique, IGC is considered to be a powerful tool to characterize powder surface. 20) In this study, we evaluated mechanofusion-processed lactose as a carrier for DPI containing Compound A, and evaluated the surface property of the lactose by IGC.…”

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confidence: 99%

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Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

et al. 2006

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Section: Inhalation Properties Of Dpi Of Compound a And Lactose Effecmentioning

confidence: 99%

mentioning

confidence: 99%

Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

et al. 2006

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“…Inverse gas chromatography (IGC) has found widespread application in the characterization of surface properties (surface energy, heat of adsorption, and specific interaction of the surface) of polymeric materials [5] and recently pharmaceuticals [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Tacticity of PMMA Adsorbed on Alumina and Silica on the Specific Entropy Change of Polymer by Inverse GC

2011

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Inverse gas chromatography (IGC) at infinite dilution is a powerful technique to characterize the superficial and interfacial properties of solid substrates as oxides, polymers or polymers adsorbed on oxides. It can also be used to determine the physicochemical properties and the transition phenomena of polymers. In this paper, IGC was used to determine the changes, as a function of temperature, of the specific free enthalpy DG a SP and deduce the specific entropy DS a SP of poly (methyl methacrylate) (PMMA) adsorbed on alumina or on silica for different tacticities of PMMA. The study of the surface properties of PMMA/SiO 2 and PMMA/Al 2 O 3 , revealed an important difference in the physicochemical behaviour of oxides covered by various concentrations of PMMA. This study also highlighted an important effect of the tacticity of the polymer on the specific entropy of PMMA adsorbed on oxides.

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“…The use of carrier particles with rougher surfaces was shown to increase [143,158,191,234,[237][238][239][240][241], decrease [21,158,242], or have no significant effect on FPF [243]. Direct proportional relationships were reported between the specific surface area of carrier powders and FPF [244,245], but the reverse trend was also reported [158,246]. Other studies indicated that there is no definite correlation between carrier powder specific surface area and FPF [247].…”

Section: Surface Propertiesmentioning

confidence: 94%

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

Kaialy

2016

Advances in Colloid and Interface Science

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Blending drug and carrier powders to produce homogeneous drug-carrier adhesive mixtures is a key step in the production of dry powder inhaler (DPI) formulations. Although the blending conditions can result in different conclusions or probably change the outcome of a study entirely if being selected differently, there is a scarcity of data on the influence of blending processes on the physicochemical properties of bulk powder formulations and the follow-on effects on DPI performance. This paper provides an overview of the interactions between variables related to blending conditions (e.g. blending equipment, time, speed and sequence as well as environmental humidity) and powder physicochemical properties (e.g. size distribution, shape distribution, density, anomeric composition, electrostatic charge, surface, and bulk properties), and their effects on the performance of adhesive mixtures for inhalation in terms of drug content homogeneity, drug-carrier adhesion, and drug aerosolisation behaviour. The relevance of carrier payload, batch size and segregation was also discussed. Challenges and future directions were identified. This review therefore contributes towards a better understanding of the blending process, powder physicochemical properties, and their interlinked effects on the fundamental understanding of adhesive mixtures for inhalation. The knowledge gained is essential to ensure optimum blending and thereby controlled functionality of DPIs.

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Abstract: A convincing relationship, potentially useful for rapid formulation design and screening, was found between the surface energy and area parameters derived from IGC and dry powder inhaler performance.

Cited by 95 publications

References 7 publications

Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

Effect of the Tacticity of PMMA Adsorbed on Alumina and Silica on the Specific Entropy Change of Polymer by Inverse GC

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

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