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Synthesis of 2,4,6-triisopropylbenzenesulfonic acid N-azolides and their regulatory effect on cell proliferation, energy expenditure, and apoptosis processes

“…Test systems for determining concentrations of total IgE, TNFa, and PGF in blood serum of pregnant rabbits considering certain differences in the antigenicity of these proteins in man and rabbits were certified beforehand in previous studies. The results confirmed the high accuracy of these diagnostic systems in working under the conditions of the developed experimental model [1,2,6].…”

“…We have previously reported on the immunomodulating and cytoprotective properties of certain methane-and benzenesulfonic acid N-azolides [1,2] and also on the antibacterial activity of b-naphthalenesulfonic acid N-azolides [3].…”

Synthesis and antimicrobial activities of novel n-substituted 8-(1-alkyl/alkylsulphonyl/alkoxycarbonyl-benzimidazol-2-ylmethoxy)-5-chloroquinolines

“…Based on spectral and analytical data, the compound was assigned the structure 8-[(1H--benzimidazol-2-yl)methoxy]-5-chloroquinoline (3). Reaction of 3 with different electrophiles [23][24][25][26] in the presence of an appropriate base yielded a series of novel benzimidazoles 4a-n, as represented in Scheme 1.…”

Reactivity of 1,2,3-triazoles towards sulfonyl chlorides. A novel approach to 1- and 2-sulfonyl-4-azolyl-1,2,3-triazoles

“…Though this reaction is recognized as a traditional method to prepare 1-sulfonyl triazoles 14 the publications with data on reactivity of 1,2,3-triazoles with sulfonyl chlorides are innumerous. 22,23,[24][25][26][27][28][29][30] The parent 1,2,3-triazole, 4-phenyl-and 4-ethoxycarbonyl-1,2,3-triazole are shown to react with tosyl chloride under basic conditions to form mainly 1-tosyl-1,2,3-triazoles with a small impurity of 2-substituted triazoles. [22][23][24] Conversely, 4-nitro-1,2,3-triazole reacts with 2,4,6-trimethylbenzene-1-sulfonyl chloride to give a mixture of 1-substituted-and 2-substituted-1,2,3-triazoles in almost equal quantity.…”